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Highly-tough hole-adjustable gel artificial blood vessel and making method thereof

A technology of artificial blood vessels with high toughness, applied in the field of gel artificial blood vessels and its preparation, can solve the problems of inability to produce in large quantities, inconvenient handling, and difficult availability of raw materials, etc., and achieve easy operation, low cost, and excellent biocompatibility Effect

Active Publication Date: 2014-01-22
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is not easy to obtain raw materials, and it is inconvenient to handle, so it cannot be mass-produced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1) Preparation of liquid A: Add 1 g of acrylamide and 0.1 g of sodium alginate to deionized water in sequence at 25°C to prepare a solution with a mass concentration of 10%, stir for 15 min, and stand still for 15 min for defoaming;

[0045] 2) Preparation of liquid B: add 0.001g of N,N'-methylenebisacrylamide and 0.1g of ammonium persulfate to deionized water in sequence at 25°C, and stir magnetically for 5 minutes until a uniform and transparent dispersion system is formed;

[0046] 3) Mixing of pre-polymerization solution: Pour the B solution prepared in step 2) into the A solution prepared in step 1), and stir magnetically for 10 minutes. When it becomes uniform and viscous, immediately add 0.002g of tetramethyl ethyl Diamine, magnetically stirred for 7min to obtain a prepolymer solution;

[0047] 4) Preparation of gel artificial blood vessel base: inject the pre-polymerization solution prepared in step 3) into a hollow tubular mold with an inner diameter of 0.2mm a...

Embodiment 2

[0051] 1) Preparation of liquid A: Add 1.2g of N-methylolacrylamide and 0.15g of sodium alginate to deionized water in turn at 25°C to prepare a solution with a mass concentration of 12%, stir for 20 minutes, and stand still for 30 minutes to defoam ;

[0052] 2) Preparation of liquid B: Add 0.0015g of N,N'-methylenebisacrylamide and 0.012g of potassium persulfate to deionized water in sequence at 25°C, and stir magnetically for 10 minutes until a uniform and transparent dispersion system is formed;

[0053] 3) Mixing of pre-polymerization liquid: Pour the B liquid prepared in step 2) into the prepared A liquid in step 1), and stir magnetically for 15 minutes. Diamine, magnetically stirred for 8min to obtain a prepolymer solution;

[0054] 4) Preparation of gel artificial blood vessel base: inject the pre-polymerization solution prepared in step 3) into a hollow tubular mold with an inner diameter of 0.5 mm and an outer diameter of 0.65 mm, seal the port and carry out polymer...

Embodiment 3

[0058] 1) Preparation of liquid A: Add 1.5 g of methacrylamide and 0.1 g of sodium alginate to deionized water in sequence at 25°C to prepare a solution with a mass concentration of 14%, stir for 30 minutes, and stand still for 30 minutes to defoam;

[0059] 2) Preparation of liquid B: Add 0.0015g of ethylene glycol di(meth)acrylate and 0.015g of potassium persulfate into deionized water in turn at 25°C, and stir magnetically for 5 minutes until a uniform and transparent dispersion system is formed;

[0060] 3) Mixing of pre-polymerization solution: Pour the B solution prepared in step 2) into the A solution prepared in step 1), and stir it magnetically for 10 minutes. Amine, magnetically stirred for 5 minutes to obtain a prepolymer solution;

[0061] 4) Preparation of gel artificial blood vessel base: inject the pre-polymerization solution prepared in step 3) into a hollow tubular mold with an inner diameter of 1 mm and an outer diameter of 1.2 mm, seal the port and carry out...

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Abstract

The invention relates to a highly-tough hole-adjustable gel artificial blood vessel and a making method thereof. The gel artificial blood vessel contains, by mass, 9-15% of an olefin monomer M1, 1-3% of a biological polymer M2, 0-0.02% of a chemical crosslinking agent M3 and 4-10% of an ionic crosslinking agent M4. The making method comprises the following steps: making a gel artificial blood vessel base by using the M1 and M2 as functional monomers and the M3 as a chemical crosslinking agent in an aqueous solution, and reinforcing by utilizing the M4 as an ionic crosslinking agent to make the highly-tough hole-adjustable gel artificial blood vessel. The gel artificial blood vessel made through the method has the advantages of high strength, toughness and resilience, difficult damage under the action of external forces comprising the pulling, bending, twisting and the like, rapid original shape recovery, multi-crosslinked network structure, and adjustment of the hole dimension through a crosslinking degree. The gel artificial blood vessel is suitable for the biological field, the medical field, the tissue engineering field, the adsorption field and the like.

Description

technical field [0001] The invention relates to the fields of polymer materials, biomedicine and tissue engineering, in particular to a gel artificial blood vessel with high toughness and adjustable pores and a preparation method thereof. Background technique [0002] Blood vessels are the pipelines that transport blood in the living body. In the human body, except for the cornea, hair, nails, dentin, and epithelium, blood vessels spread all over the body. Blood vessels can be divided into three types: arteries, veins and capillaries. The walls of the aorta and aorta are thick and rich in elastic fibers, which are expandable and elastic. Capillaries have the smallest caliber, the largest number, the largest total cross-sectional area, the slowest blood flow, and the thinnest wall. They are only composed of a single layer of endothelial cells and a basement membrane. material exchange. With the development of medical technology, it is necessary to study and transplant bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/56A61L27/24A61L27/22A61L27/20A61L27/18A61L27/16A61L27/14C08J7/12C08F251/00C08F289/00C08F251/02C08F283/02C08F283/04C08F261/04
Inventor 张青松张念一薛蕊梁聪聪穆齐峰陈莉
Owner TIANJIN POLYTECHNIC UNIV
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