Salicylic acid-loaded vitamin E microemulsion and preparation method thereof

A technology of salicylic acid and vitamins, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., to achieve the effect of not easy to crystallize, simple preparation process, and increased antioxidant effect

Active Publication Date: 2014-01-22
广州智园生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no compounding of ve and isopropyl myristate as the oil phase to prepare microemulsions loaded with salicylic acid

Method used

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  • Salicylic acid-loaded vitamin E microemulsion and preparation method thereof
  • Salicylic acid-loaded vitamin E microemulsion and preparation method thereof
  • Salicylic acid-loaded vitamin E microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0025] (1) Accurately weigh 0.01g of salicylic acid and dissolve it in 3g of absolute ethanol.

[0026] (2) 3 g of Tween-80, 0.066 g of vitamin E, and 0.034 g of isopropyl myristate were added respectively, and the mixture was stirred for 1 min at a rotational speed of 100 rpm.

[0027] (3) Add 3.89 g of deionized water dropwise with a pipette. After the dropwise addition, the mixture is stirred at 300 rpm for 6 hours in a sealed manner to obtain a bright yellow transparent vitamin E microemulsion (10 g) loaded with salicylic acid.

[0028] The obtained vitamin E microemulsion loaded with salicylic acid was analyzed by a nanometer particle size analyzer, and the particle size was 28.2nm.

[0029] The obtained vitamin E microemulsion loaded with salicylic acid was subjected to centrifugation stability and temperature stability research: take 10mL microemulsion diluted 100 times and put it in a 10mL colorless transparent centrifuge tube, observe after centrifugation at 4000rpm f...

Embodiment example 2

[0032] (1) Accurately weigh 0.03g of salicylic acid and dissolve it in 2.625g of absolute ethanol solution.

[0033] (2) 2.625g of Tween-80, 0.4g of vitamin E, and 0.2g of isopropyl myristate were added respectively, and the mixture was stirred for 2min at a speed of 200rpm.

[0034] (3) Add 4.12g of deionized water dropwise with a pipette. After the dropwise addition, the mixture is sealed and stirred at a speed of 400rpm for 9h to obtain a bright yellow transparent vitamin E microemulsion loaded with salicylic acid (10g) .

[0035] The obtained vitamin E microemulsion loaded with salicylic acid was analyzed with a nanometer particle size analyzer to obtain a particle size of 30.1nm

[0036] The vitamin E microemulsion loaded with salicylic acid was studied for centrifugal stability and temperature stability. The microemulsions were all clear and transparent, and the results showed that they had centrifugal stability and temperature stability.

[0037] The change test of e...

Embodiment example 3

[0039](1) Accurately weigh 0.05g of salicylic acid and dissolve it in 2.25g of absolute ethanol solution.

[0040] (2) Add 2.25g of Tween-80, 0.733g of vitamin E, and 0.367g of isopropyl myristate respectively, and stir the mixture for 3 minutes at a speed of 300 rpm.

[0041] (3) Add 4.35g of deionized water drop by drop with a pipette. After the drop is completed, the mixture is sealed and stirred at a speed of 500rpm for 12 hours to obtain a bright yellow transparent bright yellow transparent vitamin E microemulsion loaded with salicylic acid (10g).

[0042] The obtained vitamin E microemulsion loaded with salicylic acid was analyzed with a nanometer particle size analyzer to obtain a particle size of 29.5 nm.

[0043] The vitamin E microemulsion loaded with salicylic acid was studied for centrifugal stability and temperature stability. It was observed that the microemulsion remained clear and transparent, and the results showed that it had centrifugal stability and tempe...

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Abstract

The invention relates to a salicylic acid-loaded vitamin E microemulsion and a preparation method thereof. Through a synergistic effect of the antioxidant effect of vitamin E and the antimicrobial and disinfectant effect of salicylic acid, the antioxidant effect is improved. The salicylic acid-loaded vitamin E microemulsion comprises the following components: the salicylic acid, Tween-80, absolute ethanol, vitamin E, isopropyl myristate and water; and the salicylic acid-loaded vitamin E microemulsion has the particle size of 10-60nm. The preparation method comprises the following steps: dissolving the salicylic acid into the absolute ethanol; adding the Tween-80, the vitamin E and the isopropyl myristate respectively, and stirring a mixed solution; adding deionized water; and sealing and stirring the mixed solution to obtain a light yellow transparent microemulsion. The salicylic acid-loaded vitamin E microemulsion improves the solubility, the dispersibility, the dialysis and the stability of the Vitamin E in water, improves the utilization and the absorbance, and is easily processed; and the salicylic acid-loaded vitamin E microemulsion, as a transdermal drug delivery carrier, is combined with a pharmaceutically acceptable excipient, and can be prepared into a high-bioabsorption, safe, stable and convenient transdermal drug delivery preparation by an appropriate preparation method.

Description

technical field [0001] The invention belongs to the field of medicine and cosmetics, and relates to a vitamin E microemulsion loaded with salicylic acid and a preparation method thereof. Background technique [0002] In 1829, French pharmacist Leroux discovered salicylic acid from the extraction of willow bark. It is used in cosmetics to soften keratin, and the State Food and Drug Administration stipulates that the maximum concentration added to cosmetics is 2%. Salicylic acid is a fat-soluble component with a large molecular weight, which can lock the effect in the superficial cutin without affecting the active epidermal cells. Salicylic acid is a sharp tool for removing acne and shrinking pores: its fat-soluble properties can be combined with fat It can easily penetrate into the stratum corneum and into the oil-filled pores, and it can penetrate into the deep layer of the pores along the oil-secreting sebaceous glands, destroy the desmosomes between the horny cells, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/06A61K8/368A61Q19/08A61Q19/00
Inventor 魏坤魏诗琪
Owner 广州智园生物科技有限公司
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