Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Absorbable anti-adhesion film for cardiac surgery and its preparation method

A technique for cardiac surgery and anti-adhesion film, applied in the field of medical materials, can solve the problems of complex preparation method, unsuitable for industrial production, increased cost, etc., and achieves the advantages of inhibiting the growth of fibroblasts, saving medical expenses and preventing the occurrence of adhesion Effect

Active Publication Date: 2016-03-23
SAIKE SAISI BIOTECH CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method and technological process of this medical material are extremely complicated, and it is not suitable for industrial production. At the same time, more raw materials are used, which relatively increases the cost.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Absorbable anti-adhesion film for cardiac surgery and its preparation method
  • Absorbable anti-adhesion film for cardiac surgery and its preparation method
  • Absorbable anti-adhesion film for cardiac surgery and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0052] In the preparation process of the above-mentioned absorbable anti-adhesion film for cardiac surgery, the ring-opening reaction of lactide occurred in step 1), and the chemical equation is as follows:

[0053]

[0054] Step 2) A chain extension reaction occurs, and the chemical equation is as follows:

[0055]

[0056] Here m and n are determined according to the addition amount of lactide and polyethylene glycol, and the equation is used to illustrate the mechanism of the reaction vividly. The specific numerical values ​​of m and n can refer to the numerical values ​​of the examples.

[0057] The present invention also provides another method (method 2) for preparing the above-mentioned absorbable anti-adhesion film for cardiac surgery, which may include the following steps:

[0058] 1) Weigh the refined polyethylene glycol, place it in a reaction vessel, seal it, heat it at 100-150°C (preferably 140°C), and add lactide (lactide and poly The molar ratio of ethyle...

Embodiment 1-6 and comparative example 1

[0078] Examples 1-6 The absorbable anti-adhesion film used in heart surgery of the present invention, the components of Comparative Example 1 and the process parameters of Preparation Method 1 are shown in Table 1-1.

[0079] Table 1-1

[0080]

[0081]

[0082] The components of the absorbable anti-adhesion film used for heart surgery in Examples 1-6 of the present invention and Comparative Example 1 and the process parameters of Preparation Method 1 are shown in Table 1-1. Taking Example 1 as an example, the present invention implements The preparation method of example 1-6 and comparative example 1 comprises the following steps:

[0083] 1) Weigh 30.0g (0.0030 mole) of refined polyethylene glycol and place it in a 250mL three-necked flask, seal it, heat it at 100°C, and after it melts, add 70.0g (0.486 mole) of lactide, and lactide The molar ratio of ester to polyethylene glycol is 162:1, after melting, add catalyst stannous octoate (Sn(oct) 2 ) 0.020g (0.000049 mol...

Embodiment 7-12 and comparative example 2

[0106] Examples 7-12 The absorbable anti-adhesion film used in heart surgery and the components of Comparative Example 2 and the process parameters of the second preparation method are shown in Table 2-1.

[0107] table 2-1

[0108]

[0109] The components of the absorbable anti-adhesion film used for heart surgery in Examples 7-12 of the present invention and Comparative Example 2 and the process parameters of Preparation Method 1 are shown in Table 2-1. Taking Example 7 as an example, the present invention implements The preparation method of example 7-12 and comparative example 2 comprises the following steps:

[0110] 1) Weigh 15.0g (0.0015 moles) of refined polyethylene glycol and place it in a 250mL three-neck flask, seal it, heat it at 100°C, and after it melts, add 70.0g (0.486 moles) of lactide, lactide The molar ratio of ester to polyethylene glycol is 324:1, after melting, add catalyst stannous octoate (Sn(oct) 2) 0.020g (0.000049 moles), the amount of catalyst...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile strengthaaaaaaaaaa
suture strengthaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses an absorbable anti-adhesive membrane for cardiac surgery and a preparation method of the absorbable anti-adhesive membrane. The absorbable anti-adhesive membrane is a membrane prepared by a copolymer of 30wt%-60wt% of polyethylene glycol and 40wt%-70wt% of lactide. The absorbable anti-adhesive membrane is a colorless membrane free of impurity and having good elasticity and flexibility, can provide a temporary physical barrier on a chest wall and the surface of a heart without being protected by a pericardium to prevent adhesion, has the advantages of safety (no found toxicity, irritancy and pyrogen reaction), good biocompatibility, easiness in obtaining of raw materials, and convenience for surgical operation, is absorbable and degradable in vivo, good in adhesivity with a wound surface of an organism and capable of being degraded by the organism, and the degradation product can be absorbed and utilized by the organism without side effect. The absorbable anti-adhesive membrane can be used for anti-adhesion in the cardiac surgery and is convenient, safe and effective.

Description

technical field [0001] The invention belongs to medical materials, in particular to an absorbable anti-adhesion film for heart surgery and a preparation method thereof. Background technique [0002] At present, the proportion of cardiac reoperation is about 10%-20%, and the reasons for reoperation mainly include the following categories: (1) re-obstruction after aortic-coronary artery bypass grafting; (2) degeneration of valve function after valve replacement or calcification; (3) severe infection after cardiac surgery; (4) radical cure of congenital heart disease after one-stage palliative surgery; (5) severe residual obstruction or residual shunt after cardiac surgery, etc. These patients often require longer operation time during reoperation, and the incidence of complications is significantly higher than that of the first operation. The reason is that apart from poor cardiac function and general condition of the patient, another reason is the adhesion after the operatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/664A61L31/06A61L31/14C08G18/48
Inventor 赵艳刘慧侯佩国曹德伟侯昭升赵文兴
Owner SAIKE SAISI BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com