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New application of isorhamnetin

A new technology of isorhamnetin, which is applied in the application field of medicine or health food, and can solve the problems of medicine or health food without isorhamnetin enteritis

Inactive Publication Date: 2013-12-25
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, there is no relevant report that isorhamnetin can be used as an active ingredient in the preparation of medicine or health food for the treatment of enteritis

Method used

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  • New application of isorhamnetin
  • New application of isorhamnetin
  • New application of isorhamnetin

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Experimental program
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Embodiment

[0024] 1. Experimental materials

[0025] 1.1 Medicinal materials

[0026] Isorhamnetin (CAS: 480-19-3, molecular weight 316.26, HPLC purity ≥ 98%, Chengdu Master Biotechnology Co., Ltd.); Dextran sodium sulfate (DSS, CAS: 9011-18-1, molecular weight 35000 ~44000, produced by MP Biomedical LLC); sulfasalazine (SASP, CAS: 599-79-1, molecular weight 398.39, HPLC purity ≥ 98%, produced by Sigma).

[0027] 1.2 Experimental animals

[0028] C57BL / 6 mice (8-10 weeks) with a body weight of 20±2g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SYXK (Shanghai) 2009-0069. Placed in a conventional feeding environment, free access to food and water.

[0029] 2. Experimental method

[0030] 2.1 Establishment of ulcerative colitis model

[0031] Select C57BL / 6 mice with uniform body weight (20±2g, 8-10 weeks), add DSS to distilled water to make a 5% (w / v) solution, and give the mice free to drink directl...

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Abstract

The invention discloses a new application of isorhamnetin, and the new application means that isorhamnetin is taken as an active component for preparation of medicaments or health food for treating enteritis. Research results show that: isorhamnetin is capable of obviously improving symptoms such as body weight loss, bloody stools, colon shortening and tissue pathological damage and the like of ulcerative colitis mice, and inhibiting expression of colon tissue inflammatory cytokines TNF-alpha and IL-6. Therefore isorhamnetin can be taken as the active component expected to be developed as the medicaments or health food for treating enteritis, and especially is expected to be developed as medicaments or health food for treating ulcerative colitis.

Description

technical field [0001] The invention relates to a new application of isorhamnetin, in particular to the application of isorhamnetin in preparing medicine or health food for treating enteritis, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Ulcerative colitis (UC) belongs to inflammatory bowel disease (Inflammatory bowel disease, IBD). Environmental, microbial and other factors are closely related. The clinical manifestations are mainly diarrhea, abdominal pain, mucus pus and blood in the stool and recurrent attacks. Colonoscopy showed mucosal hyperemia, edema, erosion, bleeding and ulcers. Foreign epidemiological data show that the disease can occur at any age, and it is more common in young adults aged 20-40. In recent years, with the improvement of living standards and changes in diet structure and lifestyle, the incidence rate in my country has been increasing year by year. The disease has a long course and recurrent ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/00A61P1/04A23L1/29A23L33/00
Inventor 窦薇王峥涛张晶晶杨莉丁丽丽
Owner SHANGHAI UNIV OF T C M
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