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Real-time release detection method for ginkgo leaf medicinal material

A real-time release and detection method technology, applied in the field of process analysis, can solve problems affecting the quality of finished traditional Chinese medicine preparations, and achieve the effects of improving quality control, good stability, and ensuring integrity and safety

Active Publication Date: 2013-12-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Ginkgo biloba is one of the raw materials commonly used in the production of traditional Chinese medicine preparations in my country, but it has a wide range of sources and varieties, and the quality of the same variety of medicinal materials varies due to differences in growth conditions, harvest seasons, processing methods, and storage conditions.
If these raw materials of ginkgo biloba with uneven quality are directly used in subsequent production processes such as extraction and concentration of preparations, it will affect the quality of finished Chinese medicine preparations

Method used

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  • Real-time release detection method for ginkgo leaf medicinal material
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  • Real-time release detection method for ginkgo leaf medicinal material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Real-time release detection method for the quality and quantification of ginkgo biloba medicinal materials

[0032] (1) Near-infrared spectrum data collection of ginkgo biloba medicinal materials

[0033] After crushing 183 Ginkgo biloba medicinal materials, pass through a 80-mesh sieve to obtain Ginkgo biloba medicinal powder with a relatively uniform particle size; accurately weigh 2 g of Ginkgo biloba medicinal powder, place it in a weighing bottle, keep the surface of the powder flat, and use diffuse reflection The near-infrared spectrum was collected by the method, with air as the reference, the number of scans was 32, and the resolution was 8 cm -1 , the scanning spectral range is 4000-10000 cm -1 , repeatedly collected the spectra of 183 ginkgo biloba medicinal materials.

[0034] (2) Determination of quality control indicators of ginkgo biloba medicinal materials

[0035] ①Moisture determination method ： The water content of ginkgo biloba was determ...

Embodiment 2

[0052] Example 2: A real-time release detection method for the qualitative quality of ginkgo biloba medicinal materials

[0053] (1) Near-infrared spectrum data collection of ginkgo biloba medicinal materials

[0054] Precisely weigh 2 g of ginkgo biloba medicinal powder, put it in a weighing bottle, keep the surface of the powder flat, and collect near-infrared spectra by diffuse reflectance method, with air as the reference, the number of scans is 32, and the resolution is 8 cm -1 , the scanning spectral range is 4000-10000 cm -1 , repeated collection of spectra of 183 batches of ginkgo biloba medicinal materials.

[0055] (2) Spectral preprocessing

[0056] In the process of collecting the near-infrared slow reflectance spectrum of ginkgo biloba medicinal materials, the particle size, powder thickness, and powder surface properties of the medicinal material powder will all affect the near-infrared spectrum. The first-order derivative can obviously eliminate the baseline ...

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Abstract

The invention provides a real-time release detection method for ginkgo leaf medicinal material. The method comprises the following steps: collecting ginkgo leaf medicinal material in different places of production and different batches; detecting contents of water, extracts and flavonoid glycosides in ginkgo leaves; collecting near-infrared spectroscopic data of ginkgo leaf medicinal material powder; establishing a quantitative analysis model and a real-time release quantitative standard for each quality control index of ginkgo leaves; establishing a qualitative analysis model and a real-time release qualitative standard for quality evaluation of ginkgo leaves. The near-infrared spectroscopic data is introduced into the real-time release detection method for ginkgo leaf medicinal material, the method is used for quickly detecting the contents of water, extracts and flavonoid glycosides in ginkgo leaves and judging whether the quality of the medicinal material is qualified, real-time release detection is performed on the ginkgo leaf medicinal material according to quantitative and qualitative detection results, and only the medicinal material in accordance with both qualitative and quantitative real-time release standards can be released for subsequent production technical process, thus the stability and uniformity of ginkgo leaf preparations in different batches are ensured, and the quality level of the ginkgo leaf preparations is improved.

Description

technical field [0001] The invention belongs to the technical field of process analysis, and in particular relates to a real-time release detection method for ginkgo biloba medicinal materials. Background technique [0002] Ginkgo biloba is a plant of the Ginkgo family Ginkgo biloba ( Gonkgobiloba The dry green leaves of L.), the active ingredients are mainly flavonol glycosides and terpenoid lactones, which have high health care and medicinal value, and are deeply valued by scholars and entrepreneurs at home and abroad. It is recorded in Chinese Pharmacopoeia that Ginkgo biloba has the functions of astringing the lungs, relieving asthma, promoting blood circulation and removing blood stasis, and relieving pain. At present, Ginkgo biloba is one of the raw materials commonly used in the production of traditional Chinese medicine preparations in my country, but it has a wide range of sources and varieties, and the quality of the same variety of medicinal materials varies due...

Claims

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Application Information

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IPC IPC(8): G01N21/35G01N30/02
Inventor 金叶刘雪松陈勇杜文俊耿姝吴永江
Owner ZHEJIANG UNIV
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