A kind of preparation method and application of n-acyl acidic amino acid or its salt

Abstract

The invention discloses a preparation method of N-acyl acidic amino acid or its salt, which comprises the amidation reaction of fatty acid chloride and amino acid under alkaline conditions, and is characterized in that the amidation reaction uses water as a solvent and acidic Amino acid or its salt is used as the main raw material, and a small amount of neutral amino acid or its salt is used as an auxiliary raw material. Under the condition of stirring, the fatty acid chloride is firstly added dropwise to the aqueous solution of acidic amino acid or its salt, and the pH value of the reaction solution is adjusted by adding alkali; After the fatty acid chloride is added dropwise to a certain amount, add the aqueous solution of neutral amino acid or its salt, continue to drop the fatty acid chloride until the dropwise addition is completed, and stir to maintain the reaction. The method uses mixed amino acids and fatty acid chlorides to react in an aqueous phase system, which can significantly increase the conversion rate of amino acids and acid chlorides, greatly reduce the amount of residual amino acids, and the products can be directly used as surfactants after simple treatment, and the cost is greatly reduce.

Description

technical field [0001] The invention relates to a surfactant N-acyl amino acid or a salt thereof, in particular to a preparation method of an N-acyl acidic amino acid or a salt thereof, which is a low-cost preparation method of a fatty acyl acid amino acid surfactant; And the application of the N-acyl acidic amino acid prepared by the method. Background technique [0002] N-acyl amino acid or its salt is a kind of compound obtained by acylation of amino acid, usually formed by condensation of fatty acid chloride and amino acid. This type of compound has good surface activity, foaming performance, cleaning performance and mildness, and is widely used in Cosmetics, personal cleaning and care products, and also have broad applications in other fields such as food additives, metal processing, ore flotation, oil extraction, and agriculture, biological products and drug preparation. [0003] N-acyl acidic amino acid or its salt is a kind of compound obtained by amidation of acidi...

AI Technical Summary

Problems solved by technology

Since the acidic amino acid uses water as a solvent in the condensation with acid chloride, its conversion rate is relatively low, usually only 70%, the product quality is low, and the post-treatment is complicated. In actual production, polar organic solvents are mostly used, which can greatly increase the conversion rate to 85-90%, but the problem is that the post-processing is complicated and the cost rises sharply, resulting in high product prices and cannot be used on a large scale like neutral amino acid surfactants

[0004] U.S. Patent US6008390 discloses that in the aqueous phase reaction system, the conversion rate of glutamic acid can be increased to about 85% under the working conditions of a high-energy agitator, but the energy consumption of this process will increase significantly, and it is very difficult to scale up large-scale industrial production equipment At the same time, high-speed stirring leads to too much foam, which reduces the reaction mixing effect, which undoubtedly brings difficulties to production and greatly increases production costs, affecting its market application.

Moreover, in the above-mentioned preparation process, glutamic acid is too much in excess, the cost is high, and the residual amino acid brings trouble to the use in the product.