Hydroxypropyl methylcellulose enteric empty capsule jellied by carrageenan and potassium citrate

Abstract

The invention discloses a hydroxypropyl methylcellulose enteric empty capsule jellied by carrageenan and potassium citrate, which belongs to the technical field of empty capsule production, is characterized in that the hydroxypropyl methylcellulose is taken as the main raw material and mixed with the carrageenan and the potassium citrate under a special condition and has the following benefits: disintegration is timely, water content is low, the hydroxypropyl methylcellulose enteric empty capsule is suitable for medicine having strong hygroscopicity and being sensitive to water diversion, the dissolution medium has less impact on the capsule shell, and the pharmacal compliance is high; the period of validity for storage is three to four years without going bad, the requirement on the conditions for storage and transportation is low, and the capsule is difficult to break under a low humidity environment or difficult to deform, rot and go bad under a high temperature environment; the pure plant fiber conforms to the demands of people with different cultural backgrounds; non-pollution is realized during the production process, and the tailing can be redissolved and utilized; the frequently-used surface active agent and plasticizer are eliminated, the potassium citrate is utilized to jelly the carrageenan so as to decrease the gelation temperature and accelerate the gelation speed, the additive is reduced, the production cost is decreased, and the hydroxypropyl methylcellulose enteric empty capsule jellied by carrageenan and potassium citrate is suitable for large-scale popularization.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule made of carrageenan and potassium citrate gel prepared from hypromellose as a raw material. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes The good medicine is no longer bitter; because the hollow capsules are easy to swallow and can effectively mask the unpleasant taste and smell of the contents, they are becoming more and more popular among patients. [0003] The current hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In my country, gelatin hollow capsules account for the vast majority. At present, gelatin hollow capsules...

AI Technical Summary

Problems solved by technology

[0004] However, gelatin capsules obviously have the defect of slow disintegration speed. At the same time, the huge gelatin empty capsule market and its industrial chain have also brought many quality problems and safety risks.

After the "Chromium Exceeding Standard Capsule Incident", more attention has been paid to the safety issues of capsules; at the same time, with the occurrence of animal diseases such as "mad cow disease" and "foot-and-mouth disease", people have a lot of interest in making gelatin raw materials from animal leather and bones. There is great anxiety, the empty capsules mainly produced from animal gelatin have great potential safety hazards

[0005] In view of this, scientific research institutions at home and abroad have strengthened the research on plant-based capsules. So far, a variety of non-gelatin hollow capsules have been developed. 68%-88% pullulan, 10%-30% hypromellose, 1%-3% gel, 0.1%-0.5% coagulant, 0.1%-0.5% Surfactants and 0.1%-0.3% pigments are prepared into glue and dipped in glue. This patent solves the problems of slow disintegration speed and potential safety hazards of gelatin capsules, but it is obvious in the film-forming and storage stability of the capsule body. Not enough, it also has adverse effects on certain drugs in the capsule, and the surfactant in it has been expressly banned