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Preparation method and application of drug or health product for treatment of liver injury

A technology for health care products and liver injury, which can be used in food preparation, drug combination, pharmaceutical formulations, etc.

Inactive Publication Date: 2013-12-04
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(4) Acute hepatic, renal and pulmonary dysfunction is an extremely serious and intractable complication with a poor prognosis
Some severe liver trauma combined with rupture of large blood vessels, resulting in heavy bleeding, failed to raise and stabilize blood pressure despite active and rapid massive blood transfusion

Method used

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  • Preparation method and application of drug or health product for treatment of liver injury
  • Preparation method and application of drug or health product for treatment of liver injury
  • Preparation method and application of drug or health product for treatment of liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] In order to facilitate the application of the medicament of the present invention in the treatment of liver damage, the steps of extracting its active components are as follows:

[0093] (1) Weigh 1000g of light fermented soya bean, pulverize into a coarse powder, degrease by pressing, and use the dregs for subsequent use;

[0094] (2) Step (1) obtained medicinal residues are extracted 3 times with 70% ethanol 7000ml, each time for 2 hours, the extracts are combined, the ethanol is recovered, concentrated to a solution of 0.2g crude drug / ml, and set aside;

[0095] (3) The solution obtained in step (2) is purified by the macroporous adsorption resin of the HPD500 model of 1000ml, first eluted with 5000ml of water, and the eluent is discarded, then eluted with 70% ethanol of 10000ml, and collected and eluted Liquid, recovery of ethanol, concentration, that is, the active ingredient.

Embodiment 2

[0097] In order to facilitate the application of the medicament of the present invention to treat liver damage, it is made into a capsule by the following steps:

[0098] (1) Weigh 1000g of light tempeh, grind it into a coarse powder, degrease it by pressing, and keep the dregs for later use;

[0099] (2) Step (1) obtained medicinal residues are extracted 3 times with 6000ml of 70% ethanol, each time for 2 hours, the extracts are combined, the ethanol is recovered, concentrated to a solution of 0.15g crude drug / ml, and set aside;

[0100] (3) step (2) gained solution, adopt the macroporous adsorption resin of the HPD500 model of 1000ml to carry out purification, first use the water eluting of 5000ml, eluent is discarded, then elute with 70% ethanol of 10000ml, reclaim ethanol, Dried to obtain a dry ointment for subsequent use;

[0101] (4) Grind the dry paste obtained in step (3), pass through an 80-mesh sieve, add starch in an amount equal to the weight of the dry paste, mix...

Embodiment 3

[0103] In order to facilitate the application of the medicament of the present invention to treat liver damage, it is made into a tablet by the following steps

[0104] (1) Weigh 1000g of light fermented soya bean, crush it into a coarse powder, degrease with petroleum ether extraction method with a boiling point of 60-90°C, and prepare the dregs for later use;

[0105] (2) Step (1) obtained medicinal residues are extracted 2 times with 80% ethanol 8000ml, each time for 2 hours, the extracts are combined, the ethanol is recovered, concentrated to a solution of 0.3g crude drug / ml, and set aside;

[0106] (3) step (2) gained solution, adopt the HPD100 model macroporous adsorption resin of 1000ml to purify, first use the water elution of 10000ml, eluent is discarded, then use the 80% ethanol elution of 15000ml, reclaim ethanol concentration , dry, get a dry paste for later use;

[0107] (4) Grinding the dry paste obtained in step (3), passing through an 80-mesh sieve, adding dex...

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Abstract

The invention belongs to the field of pharmaceutical production and application and particularly discloses a preparation method and application of a drug or health product for treatment of liver injury. Pharmacological experiments show that the drug has the effects of significantly improving jasmine-induced hepatoxicity, reducing activity of mice serum ALT and AST of CCL4 chemical liver injury, reducing the level of mice serum ALT and AST of BCG and lipopolysaccharide induced immunological liver injury, and significantly protecting the liver. Medicinal materials in the drug belong to TCMs as food and drug, so that the drug can be made into drugs or health products for the treatment of liver injury.

Description

technical field [0001] The invention relates to a preparation method and application of a medicine for treating liver damage, and belongs to the field of medicine manufacture and application. Background technique [0002] Liver injury is a common clinical disease that endangers human health. Liver damage is the liver damage caused by the invasion of external factors. Liver injury is divided into pathological liver injury and chemical liver injury. [0003] The causes of liver injury mainly include violent liver injury, pathological liver injury, and chemical liver injury. Among them, violent liver injury usually manifests obviously rapidly and is severe. Pathological liver injury and chemical liver injury are the most common, but most of pathological and chemical liver injury have similar clinical manifestations and develop slowly, which is easy to be confused. 1. Liver injury caused by violent factors: 1. Open liver injury: usually stabbed or penetrating by sharp object...

Claims

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Application Information

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IPC IPC(8): A61K36/48A23L1/29A23L1/20A61P1/16A23L11/00A23L33/00
Inventor 王鑫国牛丽颖刘敏彦崔力剑刘姣李向军
Owner HEBEI MEDICAL UNIVERSITY
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