Anticancer composition and application of anticancer composition to preparation of drugs

A technology of anti-cancer drugs and compositions, applied in the field of medicine, can solve the problems of decreased chemotherapy effect, drug resistance and cross-drug resistance of ovarian cancer cells, and achieve the effect of weakening liver toxicity and improving anti-tumor effect

Inactive Publication Date: 2019-03-08
WENZHOU MEDICAL UNIV
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Problems solved by technology

However, the long-term use of chemotherapy drugs will not only induce severe drug resistance or cross-resistance of ovarian cancer cells to their chemotherapy drugs, resulting in decreased chemotherapy effect or even chemotherapy failure.
At the same time, it will cause severe liver toxicity to patients and seriously reduce the quality of life of patients.

Method used

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  • Anticancer composition and application of anticancer composition to preparation of drugs
  • Anticancer composition and application of anticancer composition to preparation of drugs
  • Anticancer composition and application of anticancer composition to preparation of drugs

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Embodiment Construction

[0019] The present invention is further described below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of application of the present invention.

[0020] In this example, the ovarian cancer drug-resistant cell line is taken as an example to illustrate that the compound of formula I (silibinin) and the first-line clinical chemotherapy drugs (cisplatin and paclitaxel) are used in the preparation of ovarian cancer-resistant cisplatin (A2780 / cis-Pt) Applications of cellular medicine. However, it should be understood that although only human ovarian cancer cisplatin-resistant (A2780 / cis-Pt) cells are used as an example to illustrate its use in combination therapy for the preparation of drugs against ovarian cancer drug-resistant cells, the present invention refers to "Ovarian cancer drug-resistant" cells refer to ovarian cancer cells that are not sensitive t...

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Abstract

The invention discloses an anticancer composition and application of the anticancer composition to preparation of drugs. The anticancer composition comprises silybin and chemotherapeutic drugs. Test results show that the combined application of silybin and chemotherapeutic drugs to preparation of drugs for resisting human ovarian cancer drug-resistant cells is capable of effectively improving thesensibility of the human ovarian cancer drug-resistant cells to the chemotherapeutic drugs and reducing hepatotoxicity induced by the chemotherapeutic drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of silibinin and first-line clinical chemotherapeutic drugs in the preparation of drug-resistant cell drugs against ovarian cancer. Background technique [0002] Silybin is a flavonoid drug, and its composition is a brass compound extracted from the seed coat of the medicinal plant Silybum marianum. Usually, it can protect the liver cells in the human body after medication, and can protect the liver from metabolism. Exceptions play an improving role. The results of modern pharmacological research show that silibinin can protect and stabilize the liver cell membrane, and it has different degrees of protection against various liver injuries caused by carbon tetrachloride, thioacetamide, phalloidine and other liver poisons. It can also inhibit the increase of alanine aminotransferase level in the human body caused by carbon tetrachloride; clinically, this drug is...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61K45/06A61P35/00A61P35/04A61K33/243A61K31/555A61K31/337A61K31/704
CPCA61K31/337A61K31/357A61K31/555A61K31/704A61K33/24A61K45/06A61P35/00A61P35/04A61K2300/00
Inventor 郑小辉钱建畅刘志国梁广
Owner WENZHOU MEDICAL UNIV
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