Multifunctional Raman probe with detection, hyperthermia and chemotherapy properties

A Raman probe, multifunctional technology, applied in the field of active targeted tumor detection and localized thermochemotherapy devices, can solve problems such as incurable tumors

Inactive Publication Date: 2013-12-04
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, it is difficult to cure the tumor with hyperthermia alone, so releasing drugs at the target site while undergoing hyperthermia will help to cure the tumor

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  • Multifunctional Raman probe with detection, hyperthermia and chemotherapy properties
  • Multifunctional Raman probe with detection, hyperthermia and chemotherapy properties
  • Multifunctional Raman probe with detection, hyperthermia and chemotherapy properties

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Embodiment Construction

[0027] The present invention will be further described in detail with the help of figures and examples below, a multifunctional Raman probe (7) device with detection and thermochemotherapy performance, including antibodies (1) and labeling molecules (2) arranged from the outside to the inside , surface-enhanced Raman spectroscopy (SERS) active nanoparticles (3), thermosensitive gel layer (4), nanomedicine (5) and magnetic nanoparticles (6), characterized in that: the antibody (1) achieves targeting properties, labeling molecules (2) and surface-enhanced Raman spectroscopy (SERS) active nanoparticles (3) to achieve high-sensitivity SERS detection, thermosensitive gel layer (4) loaded with nano-drugs (5), magnetic nanoparticles (6) in The heating under the alternating magnetic field causes the nano drug (5) to be released from the thermosensitive gel layer (4).

[0028] Antibodies (1) are proteins that can specifically bind to tumor cells. For example, a monoclonal antibody aga...

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Abstract

The invention discloses a multifunctional Raman probe device (7) with detection, hyperthermia and chemotherapy properties. The multifunctional Raman probe device is used in the field of tumor detection and therapy. The multifunctional Raman probe device comprises antibodies (1), prognostic markers (2), surface enhanced Raman spectroscopy (SERS) active nanoparticles (3), a thermo-sensitive gel layer (4), nano-drugs (5) and a magnetic nanoparticle (6). The multifunctional Raman probe device has the advantages that tumor can be detected in real time for a patient in a non-invasive and online manner, local hyperthermia and chemotherapy can be perform on a tumor focus of the patient, the tumor position of the patient can be safely and specifically treated while damage to normal tissues or cells of the patient is prevented to the greatest extent.

Description

technical field [0001] The invention relates to tumor detection and treatment, in particular to active targeting tumor detection and localized thermochemotherapy device technology. Background technique [0002] In 1974, Fleischmann first measured the Raman spectrum of pyridine on the surface of a silver electrode, which proved to be a surface-enhanced Raman spectrum (SERS) whose intensity could be enhanced by a million times. Although it is generally believed that this phenomenon is relatively complicated and it is difficult to explain it satisfactorily with a theory, this multi-million-fold enhancement has uniquely attractive development prospects and has aroused the interest of more and more analysts. , is widely used in scientific and technical fields including chemistry, biology, surface science, qualitative and quantitative analysis, etc., especially SERS technology has been developed to the level of single molecule detection, which has opened up a new situation for it...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61F7/12A61K49/00A61K47/42A61K47/30A61K47/02A61K31/704A61P35/00
Inventor 金永龙方靖淮成鸣飞施建珍曹敏王超男
Owner NANTONG UNIVERSITY
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