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C3 polypeptide supramolecular helical polymer and preparation method thereof

A supramolecular and polymer technology, which is applied in the field of C3 polypeptide supramolecular helical polymer and its preparation, can solve the problems of lack of functionalization of molecules and expensive raw materials, and achieve the effect of reliable chirality, simple preparation and low price

Inactive Publication Date: 2016-01-20
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the designed molecules lack functionalization and the raw materials are expensive

Method used

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  • C3 polypeptide supramolecular helical polymer and preparation method thereof
  • C3 polypeptide supramolecular helical polymer and preparation method thereof
  • C3 polypeptide supramolecular helical polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take 2.50mg of C 3 -GA monomer was added into 10 mL of tetrahydrofuran, and then sonicated and heated repeatedly until the monomer was completely dissolved. The solution was then left for 12 hours.

Embodiment 2

[0043] take multiple copies of C 3 -AG monomer, 2.5mg each, was added to 10mL of methanol, 10mL of propanol, 10mL of isopropanol, 10mL of n-butanol, 10mL of sec-butanol and 10mL of tetrahydrofuran, and then repeated ultrasonication and heating, until the monomer is completely dissolved. The solution was then left for 12 hours.

Embodiment 3

[0045] Take 2.50mg of C 3 -VG monomer was added into 10 mL of tetrahydrofuran, and then ultrasonic and heated repeatedly until the monomer was completely dissolved. The solution was then left for 12 hours.

[0046] Performance Tests and Uses

[0047] The circular dichroism of the above solutions was measured by circular dichroism (CD). Through the CD spectrum ( Figure 5 ) It can be seen that C 3 The tetrahydrofuran solution of -GA monomer presents negative and positive peaks at 243nm and 215nm, respectively, confirming that C 3 - The supramolecular helical polymer formed by layer-by-layer self-assembly of GA monomers has a right-handed helix, and the atomic force microscope (see Figure 8 ), observed that C 3 -GA assemblies are multi-strand winding fibers with helices.

[0048] C 3 THF solution of -AG monomer ( Figure 4 ) have negative, positive and negative peaks at 260nm, 245nm and 212nm, respectively, which proves that the supramolecular polymer has a left-hand...

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Abstract

The invention relates to providing a C3 polypeptide supramolecular helical polymer and a preparation method thereof. Polypeptide supramolecular helical polymers are made of monomer molecules through the amidation reaction of pentafluorophenol active esters of trimesic acid and dipeptides modified with alkyl chains, and then the monomer molecules self-assemble into supramolecular helical polymers in solution , the chirality of supramolecular helical polymers can be changed by changing the sequence of amino acids, and the helical pitch of supramolecular helical polymers can be adjusted by changing the chirality of amino acids. The preparation of supramolecular helical polymers is simple, and the chiral source (amino acid) used in it is obtained through natural proteolysis, non-synthetic, reliable chirality, cheap, and can be used in many fields such as chiral recognition and chiral separation. And it provides a new method for the preparation of new chiral materials.

Description

technical field [0001] The invention relates to a supramolecular helical polymer and a preparation method thereof. especially a C 3 Polypeptide supramolecular helical polymer and its preparation method. Background technique [0002] Helical polymers have attracted extensive attention from the scientific community for their unique optical activity. The study of helical polymers is not only of theoretical significance, but also the study of the conditions for helix formation, the conditions that affect the helical pitch, and the conditions for helical chirality reversal are of great importance for the understanding of gene expression and gene expression in the biological world. Mutation and protein denaturation are of inestimable value, and helical polymers can be used for chiral recognition, chiral separation, and chiral catalysis. Supramolecules are small molecules that self-assemble into macromolecular polymers with regular structures through weak interactions such as hyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C07K5/062C07K1/02
Inventor 张阿方代玉堂王芳
Owner SHANGHAI UNIV
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