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Gradient degradable polymer material and preparation method thereof

A polymer material and gradient technology, applied in the field of medical biomaterials, can solve problems such as uncontrollable degradation sequence, hidden dangers for patients, and inorganic salt deposition, and achieve ideal degradation time, large economic and social values, and good biocompatibility Effect

Active Publication Date: 2015-11-18
山东省新征程工业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Although some progress has been made in the development of the above-mentioned degradable ureteral stents, some problems exist, such as being made of uniform materials, the degradation probability of each part of the stent is the same, and the degradation sequence is uncontrollable, which may cause Ureteral obstruction; hard texture, poor hydrophilicity and tissue compatibility, easily lead to inorganic salt deposition on the surface of the stent, conjunctiva, and bring greater hidden dangers to patients, etc., indicating that there is still a lot of room for development

Method used

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  • Gradient degradable polymer material and preparation method thereof
  • Gradient degradable polymer material and preparation method thereof
  • Gradient degradable polymer material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 0.833g D, L-lactide, 0.167g glycolide, 0.08g PEG200, 0.001g zinc acetate respectively, add to the test tube, then add a magnetic stirrer, vacuum / nitrogen cycle 3 times, and The mouth of the test tube was melted and sealed under vacuum conditions, and placed in an oil bath at 140° C. to react for 24 hours to obtain a linear polymer.

Embodiment 2

[0044] Weigh 0.555g L-lactide, 0.176gε-caprolactone, 0.08g PEG200, 0.001g zinc lactate respectively, add them into the test tube, then add a magnetic stirrer, vacuum / nitrogen cycle 3 times, and vacuumize Under the conditions, the mouth of the test tube was melted and put into an oil bath at 140° C. for 24 hours to react to obtain a linear polymer.

Embodiment 3

[0046] Weigh 0.833g D, L-lactide, 0.126g glycolide, 0.041gε-caprolactone, 0.08g PEG4000, 0.001g zinc sulfate, add into the test tube, add a magnetic stirrer, vacuumize / fill with nitrogen Circulate 3 times, seal the mouth of the test tube under vacuum conditions, put it into an oil bath at 140°C and react for 24 hours to obtain a linear polymer.

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Abstract

A polymer material capable of gradient degradation. The polymer material is formed by at least two types of aliphatic polyesters having different degradation velocities, the aliphatic polyesters being arranged in an ascending order or descending order of the degradation velocities and fused together. The polymer material may be manufactured as thread materials, barrier materials, tube materials, and controlled drug release carriers, which specifically comprise sutures, medical dressings, adhesion prevention material, hemostasis material, guided tissue regeneration barriers, tissue repair materials, enhancement surgical meshes, drug carriers, cartilage tissue culture scaffolds, scaffolds, and especially urethral scaffolds.

Description

technical field [0001] The invention relates to the field of medical biomaterials and technology, in particular to a gradient degradable polymer material and a preparation method thereof. Background technique [0002] The heterogeneity of gradient-degradable polymers requires that the polymers that make up different parts of the product degrade at different rates. The degradation rate of polymers is affected by several factors, such as structure, molecular weight, composition, etc. [0003] For polymers with the same composition, the degradation rate decreases as the molecular weight increases; aliphatic polyesters with different compositions can be prepared by adjusting the ratio of different monomers and changing the type and amount of initiator; the degradation rate of the polymer It will increase with the increase of polyglycolic acid content, and increase with the increase of hydrophilic segment content, so as to achieve the purpose of regulating the degradation rate. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/00C08L67/04C08G63/664C08G63/08C08G63/60C08G63/64C08G63/695A61L17/10A61L17/12A61L15/26A61L15/62A61L15/64A61L31/06A61L31/14A61L27/18A61L27/58A61L29/06A61L29/14A61K47/34A61K49/04C12N5/071A61F2/82A61M25/00
CPCA61L27/18A61L17/12A61L27/58A61L31/06A61L31/148C08L67/04
Inventor 张文芳蔡洪
Owner 山东省新征程工业科技有限公司
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