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Medicinal composition containing pentoxifylline and prucalopride and medical application thereof

A technology of pentoxifylline and a composition, applied in the field of medicine, can solve the problems of inability to effectively improve constipation symptoms, not involving a pharmaceutical composition, lack of outlet obstruction type constipation, etc., achieving broad medical application prospects, improving constipation symptoms, treating full effect

Active Publication Date: 2013-10-23
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(4) Lack of evidence of outlet obstruction constipation, such as normal balloon expulsion test and normal anorectal manometry
[0004] The treatment of chronic constipation usually uses more laxatives, but laxatives cannot effectively improve the symptoms of constipation. A study in 2008 showed that although 16%-40% of patients with constipation used laxatives, the symptoms Still present, no significant difference compared to patients not using laxatives
A 2007 web-based survey showed that 47% of patients were not completely satisfied with laxatives, 82% due to poor efficacy and 16% due to safety
CN10214500A discloses the medical use of pentoxifylline for preventing or treating functional constipation, and specifically discloses a pharmaceutical preparation containing pentoxifylline, but the medical use and pharmaceutical preparation do not involve the pharmaceutical composition of the present invention

Method used

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  • Medicinal composition containing pentoxifylline and prucalopride and medical application thereof
  • Medicinal composition containing pentoxifylline and prucalopride and medical application thereof
  • Medicinal composition containing pentoxifylline and prucalopride and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 compound tablet

[0036]

[0037] Preparation process: mix pentoxifylline and prucalopride with auxiliary materials microcrystalline cellulose and starch evenly, add appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0038] The preparation of embodiment 2 compound tablet

[0039]

[0040] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0041] Example 3 Preparation of compound bilayer tablet

[0042]

[0043] Preparation process: pentoxifylline is passed through a 100-mesh sieve, hydroxypropyl methylcellulose-4M and microcrystalline cellulose are passed through a 80-mesh sieve, and the prescribed amount of pentoxifylline and hydroxypropyl methylcellulose-4M is weighed , microcrystalline cellulose mixed evenly, adding 8% PVP absolute ethanol solution to granulate in an appropriate amount, drying at 60°C, sieving the dry granules with a 16-mesh sieve, adding magnesium stearate of the prescription amount in the dry granules.

[0044]

[0045] Preparation process: Prucalopride is passed through a 100-mesh sieve, sodium carboxymethylcellulose and lactose are passed through a 80-mesh sieve, the prescribed amount of prucalopride, sodium carboxymethylcellulose and lactose are weighed and mixed evenly, and 6% PVP is added. Appropriate amount of 95% ethanol solution is granulated, dried at 60° C., sieved with 16 ...

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PUM

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Abstract

The invention discloses a medicinal composition for treating constipation. According to the medicinal composition, pentoxifylline and prucalopride or medicinally usable salts thereof are used as main active ingredients. The medicinal composition can obviously improve the intestinal transmission function and reduce the pressure of sphincter ani; and an obvious synergistic effect is achieved after the two medicaments are combined. The medicinal composition has clear ingredients, a clear curative effect and a treatment effect of treating both symptoms and root causes of chronic constipation, particularly functional constipation, and thus has a broad medical application prospect.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its pharmaceutical use, in particular to a pharmaceutical composition with pentoxifylline and prucalopride as active ingredients and its medical use for treating constipation. The invention belongs to the field of medicine . Background technique [0002] Constipation is one of the most common gastrointestinal symptoms clinically. It often manifests as strained defecation, decreased frequency of defecation, induration or dry ball of defecation, feeling of incomplete defecation, anorectal blockage, and even assisted defecation with manipulation. Chronic constipation has been underestimated by people for quite a long time in the past. In recent years, the prevalence of constipation has gradually increased, and studies have shown that it is closely related to acute cardiovascular and cerebrovascular diseases, dementia, and colorectal cancer. More and more attention. [0003] Chronic consti...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/4525A61P1/10
Inventor 赵志全冯芹刘奋孙宝存
Owner LUNAN PHARMA GROUP CORPORATION
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