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Ischemic heart disease detection kit and application thereof

A technology of ischemic heart disease and a detection kit, which is applied in the field of medicine and can solve the problems of not being able to detect the concentration of IMA

Inactive Publication Date: 2013-10-09
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the ACB method cannot detect the true IMA concentration

Method used

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  • Ischemic heart disease detection kit and application thereof
  • Ischemic heart disease detection kit and application thereof
  • Ischemic heart disease detection kit and application thereof

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Embodiment Construction

[0026] patient

[0027] The specimen collection time was from January 2011 to January 2013 in Southwest Hospital Affiliated to Third Military Medical University. All participants were divided into two groups: ischemic heart disease or non-ischemic heart disease group. The non-ischemic group indicated that the diagnosis showed no signs of myocardial ischemia, or that the participants were generally healthy. The non-ischemic group consisted of 125 samples (74 males and 51 females) with a mean age of 35 years.

[0028] The average age of 64 samples (34 males and 30 females) in the ischemic group was 39.4 years. Patients with kidney disease were first excluded from this study. The clinical judgment of myocardial ischemia (MI) includes some objective clinical indicators such as: imaging examination, electrocardiogram study and serum myocardial biochemical markers. The details are as follows: obvious rise and gradual fall of troponin or more rapid rise and fall of CK-MB, and at ...

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Abstract

The invention discloses an ischemic heart disease detection kit and application thereof. The kit comprises a human serum albumin (HSA) primary antibody, an HAS secondary antibody compound coupled with QD, Co <2+> and a phosphate buffer solution (PBS) buffering solution. By the kit provided by the invention, a real ischemia modified albumin (IMA) value can be accurately detected, and the interference of ultrahigh or ultralow total HSA concentration is avoided; the detection can be completed within 20-30 minutes at high speed; the kit is particularly suitable for a biological indicator which needs to obtain a result quickly, such as the IMA.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a detection kit for ischemic heart disease and its application. Background technique [0002] Ischemic heart disease (IHD) is due to abnormal lipid metabolism. Some atheroid lipids accumulate in the arterial intima to form white plaques. These plaques gradually increase to narrow the arterial lumen and block blood flow. Leading to cardiac ischemia and angina pectoris is a common clinical cardiovascular emergency and an important cause of acute death. Ischemic heart disease (IHD) is currently the leading cause of death and disability worldwide. According to statistics, 17.6 million Americans are affected by the disease, and approximately 450,000 Americans die from the disease each year. Therefore, clinicians have been committed to finding a sensitive marker of myocardial ischemia that can be detected in the early reversible stage of IHD, which has important clinical significa...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N21/64G01N23/223
Inventor 黄君富罗阳蒋天伦府伟灵
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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