Pharmaceutical composition of paclitaxel injection

A paclitaxel and composition technology, applied in the field of pharmaceutical compositions containing paclitaxel injections, can solve the problems of less clinical use, etc., and achieve the effects of rapid dissolution and simple preparation methods

Inactive Publication Date: 2013-10-02
河北三禾实创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sodium salt of acetylsalicylic acid has the sam

Method used

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  • Pharmaceutical composition of paclitaxel injection
  • Pharmaceutical composition of paclitaxel injection
  • Pharmaceutical composition of paclitaxel injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Weigh 10g of sodium acetylsalicylate, 1g of 1,2-propylene glycol, 2g of paclitaxel plus 900ml of absolute ethanol; add 1g of activated carbon, heat and reflux for 30 minutes, filter and decarbonize, add absolute ethanol to 1000ml, and pass through a 0.45μm micropore Membranes, aseptically filled in vials, 10ml each, sterilized by circulating steam at 110°C for 1 hour.

Embodiment 2

[0047] Weigh 10g of sodium acetylsalicylate, 1g of 1,2-propylene glycol, 2g of paclitaxel plus 900ml of absolute ethanol; add 1g of activated carbon, heat and reflux for 30 minutes, filter and decarbonize, add absolute ethanol to 1000ml, and pass through a 0.45μm micropore Membranes, aseptically filled in medicine bottles, each 20ml, sterilized by circulating steam at 110°C for 1 hour.

Embodiment 3

[0049] Weigh 10g of sodium acetylsalicylate, 1g of 1,2-propylene glycol, 2g of paclitaxel plus 900ml of absolute ethanol; add 1g of activated carbon, heat and reflux for 30 minutes, filter and decarbonize, add absolute ethanol to 1000ml, and pass through a 0.45μm micropore Membranes, aseptically filled in vials, 50ml each, sterilized by circulating steam at 110°C for 1 hour.

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Abstract

The invention relates to a pharmaceutical preparation composition, in particular to a pharmaceutical composition containing a paclitaxel injection. The pharmaceutical composition consists of paclitaxel, sodium acetylsalicylate, 1,2-propylene glycol and absolute ethyl alcohol.

Description

technical field [0001] The invention relates to a pharmaceutical preparation composition, in particular to a pharmaceutical composition containing paclitaxel injection. Background technique [0002] Paclitaxel, whose English name is Paclitaxel, is a compound extracted from the bark of Taxus brevifolia. It is a specific stabilizer of microtubules, which can promote the assembly of microtubules and maintain the stability of microtubules. [0003] Its chemical name is 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytaxane-11-en-9-one-4,10-diacetate-2-benzoic acid Ester-13[(2'R,3'S)-N-benzoyl-3-phenylisoserine ester], [0004] Molecular weight 853.92, [0005] Molecular formula C 47 h 51 NO 14 . [0006] Structural formula: [0007] [0008] Paclitaxel dissolves in methanol, ethanol or chloroform, is almost insoluble in water, and the solubility in water is only 0.006mg / ml, and the effective bioavailability in the human body is low. Currently, paclitaxel injection in clinic...

Claims

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Application Information

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IPC IPC(8): A61K47/12A61K47/10A61K9/08A61K31/337A61P35/00
Inventor 贺金凤
Owner 河北三禾实创生物科技有限公司
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