Preparation method for enteric plant cellulose hard hollow capsules
A plant cellulose and hollow capsule technology, which is applied in capsule delivery, medical preparations of non-active ingredients, and pharmaceutical formulas, etc., can solve problems such as large water content differences, high water loss, and prolonged drying and molding processes, and achieve molecular Stable structure, sufficient dissolution rate and thorough dissolution effect
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Embodiment 1
[0021] Embodiment 1: Production of transparent colorless enteric-coated cellulose hard hollow capsules
[0022] Take 70 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 30 parts of hypromellose (that is, 30% of the total mass of all ingredients) and slowly add it to the water, stir evenly, and wait until When the liquid temperature drops to about 60°C, add 0.5% (mass ratio) sodium lauryl sulfate and 2% (mass ratio) sodium alginate, and continue stirring. When the temperature of the solution drops below 60°C, stop stirring. Let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven. The temperature of the oven is controlled at 50-70°C and the relative humidity is 40-60%. Coating for the first time, after the coating material is dried, then coating for the second time, then demoulding, cutting, following the conventional hard capsule production proces...
Embodiment 2
[0023] Embodiment 2: Production of colorless transparent enteric-coated cellulose hard hollow capsules
[0024] Take 75 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 25 parts of hypromellose (that is, 25% of the total mass of all ingredients), slowly add it to the water, stir evenly, and wait for When the liquid temperature drops to about 60°C, add 0.3% sodium lauryl sulfate, 0.2% Tween-80 (polysorbate-80), and 1.5% agar, and continue stirring until the solution temperature drops below 60°C , stop stirring, let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven. The temperature of the oven is controlled at 50-70°C and the relative humidity is 40-60%. After 3-4 hours , the first coating is carried out first, and the coating material is dried, and then the second coating is carried out, and then demoulding, cutting, and following the convention...
Embodiment 3
[0025] Example 3: Production of colored light-shielding enteric-coated cellulose hard hollow capsules
[0026] Take 75 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 25 parts of hypromellose (that is, 25% of the total mass of all ingredients), slowly add it to the water, stir evenly, and wait for When the liquid temperature drops to about 60°C, add 0.3% sodium lauryl sulfate, 2% Tween-80 (polysorbate-80), 1.5% agar, 0.3% pigment, 1% titanium dioxide, Continue to stir, when the temperature of the solution drops below 60°C, stop stirring, let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven, the temperature of the oven is controlled at 50-70°C, and the relative humidity is at 40-60%, after 3-4 hours, the first coating is carried out first, and the coating material is dried, and then the second coating is carried out, and then demoulding, cutti...
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