Drug granule mixing feeding tabletting all-in-one machine

Abstract

The invention relates to equipment for tabletting drug granules. In order to mix and tablet the drug granules and prepare finished drug products with uniform content, the invention provides the all-in-one machine for mixing, feeding and tabletting drug granules. According to the all-in-one machine, a mixing machine outputs a material to a tabletting machine, a feeding machine feeds the material to the mixing machine in batches, the mixing machine mixes the material in batches, a conveying mechanism for conveying the material after mixing of each batch is connected between the mixing machine and the tabletting machine, and the tabletting machine tablets the material in batches. The all-in-one machine automatically groups the drug granules in batches, and performs all-in-one processing on each batch of drug granules in time sequence; the all-in-one processing on each batch of drug granules includes feeding, mixing and tabletting operations carried out in sequence. As the tabletting capacity of each batch is less than that of the whole batch, the drug granules have low possibility of dissociation or separation during the tabletting operation, and the content of the finished drug products is uniform. The all-in-one machine for mixing, feeding and tabletting drug granules automatically accomplishes the mixing and tabletting process, and the wet granulation procedure is not required, so that the production efficiency is improved.

Description

Technical field [0001] The invention relates to a device for compressing medicine particles, and specifically provides a medicine particle mixing, feeding, and tablet pressing machine. Background technique [0002] The whole-powder direct compression process is the future development direction of tablet production in the pharmaceutical industry. It will replace the current wet granulation and tableting method, because the tableting process reduces the cumbersome steps of mixing-soft material-drying-granulation. It has the characteristics of time-saving and energy-saving, simple process and few procedures, which can greatly reduce the production cost of tablets and improve production efficiency. The foreign pharmaceutical industry mainly implements the all-powder direct compression process by changing the auxiliary materials, and there is no direct compression process research based on the idea of ​​technical improvement of the tablet press. [0003] Current research status of simi...

AI Technical Summary

Problems solved by technology

[0004] Existing problems: before tableting, the whole batch of drug granules is mixed; in the process of compressing the whole batch of drug granules, due to the vibration of the tablet machine, when using full powder direct compression, the drug granules It is easy to dissociate or segregate, resulting in large differences in the content of products within a batch, and even causing unqualified

Although the above problems can be solved by using wet granulation and tablet compression, the process of mixing soft materials-screening-drying-granulation and other processes is added, which makes the full powder direct compression process of tablets unable to be popularized.

Due to the poor fluidity of drug granules, the large difference in tablet weight, and the shortcomings of granule compression, such as cracks, etc., currently the main methods are relatively expensive microcrystalline cellulose, compressible starch, spray-dried lactose, calcium hydrogen phosphate dihydrate, and micropowder silica gel. However, the addition of excipients will reduce the mechanical strength of the tablet, prolong the disintegration time of the drug in the body, and increase the coefficient of variation of the active ingredients, which will also increase the cost of pharmaceutical companies.

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