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Patch

A technology of patches and liquid additives, which can be used in medical preparations of non-active ingredients, cardiovascular system diseases, organic active ingredients, etc., and can solve problems such as inapplicability

Inactive Publication Date: 2013-09-18
SEKISUI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the technology disclosed in Patent Document 2 cannot be applied to clonidine patches containing only free base clonidine in the prescription

Method used

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Effect test

Embodiment 1

[0098] Get liquid additive (liquid paraffin, manufactured by Kaneda Company, trade name Hicall M72) 39 parts by weight, clonidine 13 parts by weight, light silicic anhydride (manufactured by Japan Aerosil Company, trade name Aerosil200) 8 parts by weight and toluene 560 parts by weight, Stir until homogeneous to obtain a mixture. Then, add 28 parts by weight of a polymer base (A) with a viscosity average molecular weight of more than 800,000 (high molecular weight polyisobutylene: viscosity average molecular weight 1,100,000, manufactured by BASF Company, trade name Oppanol B100) and a viscosity average molecular weight of 1 to the above mixed solution. More than 10,000 and less than 800,000 polymer base (B) (low molecular weight polyisobutylene: viscosity average molecular weight 36,000, manufactured by BASF, trade name Oppanol B10SFN) 12 parts by weight, mixed uniformly, and prepared a solution for forming a paste layer. The obtained paste layer-forming solution was coated o...

Embodiment 2

[0100] Get liquid additive (liquid paraffin, manufactured by Kaneda Company, trade name Hicall M72) 38 weight parts, clonidine 3 weight parts, light silicic anhydride (Japan Aerosil company manufactures, trade name Aerosil200) 9 weight parts and toluene 560 weight parts, Stir until homogeneous to obtain a mixture. Then, add 35 parts by weight of a polymer base (A) with a viscosity average molecular weight of more than 800,000 (high molecular weight polyisobutylene: viscosity average molecular weight 1,100,000, manufactured by BASF Company, trade name Oppanol B100) and a viscosity average molecular weight of 1 to the above mixed solution. More than 10,000 and less than 800,000 polymer base (B) (low molecular weight polyisobutylene: viscosity average molecular weight 36,000, manufactured by BASF, trade name Oppanol B10SFN) 15 parts by weight, mixed uniformly, and prepared a solution for forming an adhesive layer. The obtained solution for forming an adhesive layer was coated on ...

Embodiment 3

[0102] Get 47 parts by weight of liquid additive (liquid paraffin, manufactured by Kaneda Company, trade name Hicall M72), 13 parts by weight of clonidine, 8 parts by weight of light silicic anhydride (manufactured by Aerosil Corporation of Japan, trade name Aerosil200), and 560 parts by weight of toluene, Stir until homogeneous to obtain a mixture. Then, add 29 parts by weight of a polymer base (A) with a viscosity average molecular weight of more than 800,000 (high molecular weight polyisobutylene: viscosity average molecular weight 1,100,000, manufactured by BASF Company, trade name Oppanol B100,) in the above-mentioned mixed solution. More than 10,000 and less than 800,000 polymer base (B) (low molecular weight polyisobutylene: viscosity average molecular weight 36,000, manufactured by BASF Corporation, trade name Oppanol B10SFN) 3 parts by weight, mixed uniformly, and prepared a solution for forming a paste layer . The obtained paste layer-forming solution was coated on ...

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Abstract

A patch with stable transdermal absorbability, regardless of temperature changes during storage, in a crystallized formulation of clonidine is provided. This patch is characterized by including a backing, and a plaster layer integrally laminated on one surface of the backing, said plaster layer containing 5 to 30 wt% of clonidine containing crystallized clonidine, 25 to 90 wt% of a polymer base (A) having a viscosity-average molecular weight of at least 800,000, and 5 to 60 wt% of a liquid additive capable of dissolving the clonidine. Moreover, the weight ratio of the liquid additive to the polymer base (A) [liquid additive / polymer base (A)] is 0.1 to 2.0.

Description

technical field [0001] The present invention relates to a patch, which is a clonidine crystal precipitation preparation, which has stable transdermal absorbability regardless of temperature changes during storage. Background technique [0002] Clonidine is a centrally acting antihypertensive drug that stimulates α2 receptors. Patches made using clonidine are commercially available as crystal-leaching preparations. Such a clonidine patch can continue to exert its medicinal effect for as long as one week after it is attached to the skin. However, the clonidine patch has a problem that transdermal absorbability changes due to temperature changes during storage. There is currently no effective countermeasure against this problem. Therefore, for example, the medical field requires storage of clonidine patches under strict temperature control not exceeding 30°C. Therefore, storage of the clonidine patch imposes a large burden on the medical field. [0003] Patent Document 1 d...

Claims

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Application Information

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IPC IPC(8): A61K31/4168A61K9/70A61K47/06A61K47/32A61P9/12
CPCA61K9/7046A61K31/4168A61P9/12A61K9/70A61K47/06A61K47/32A61K9/7023A61K9/7053
Inventor 宇田川弘子稻叶义和野田幸彦小端久美寺岛宽人
Owner SEKISUI MEDICAL CO LTD
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