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Surface-heparinized cellulose ester liquid crystal material and preparation method and application thereof

A technology of liquid crystal materials and cellulose, applied in liquid crystal materials, chemical instruments and methods, etc., can solve the problems of surface liquid crystal state structure change, deformation, insufficient stability of small molecule liquid crystal domains, etc., to reduce interfacial tension, mature technology, high efficiency The effect of anticoagulant properties

Active Publication Date: 2013-09-11
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main reason is that the small-molecule liquid crystal domains are not stable enough, and will be deformed (including size and orientation) by the external environment, resulting in changes in the liquid crystal state structure on the surface of the material. Relationship-Based Molecular Design of Biomaterials

Method used

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  • Surface-heparinized cellulose ester liquid crystal material and preparation method and application thereof
  • Surface-heparinized cellulose ester liquid crystal material and preparation method and application thereof
  • Surface-heparinized cellulose ester liquid crystal material and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0035] (1) Preparation of acryloyl-octanoyl-hydroxypropyl cellulose ester liquid crystal: 2 g of hydroxypropyl cellulose (M W =100,000, purchased from Aldrich Company) and dissolved in acetone solution; after complete dissolution, 1 mL of acryloyl chloride was added dropwise to it, and the reaction was carried out at 55 °C for 4 h. After the reaction, 200 mL of deionized water was added to the mixed solution to precipitate the product, and stirred for 5 h Then, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, add 200 mL of deionized water to precipitate the precipitated product, stir for 5 h, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitate in acetone, repeat the above After adding deionized water, stirring, standing, removing water, and dissolving the precipitate in acetone for 5 times, at 25 °C, dialyzed in deionized water for 48 h to remove residual acryloyl chloride, and dried; then the obtai...

Embodiment 2

[0051] (1) Preparation of acrylated-octanoylated-hydroxypropyl cellulose ester liquid crystal: 1 g of hydroxypropyl cellulose (M W = 200,000, purchased from Aldrich Company) and dissolved in acetone solution; after complete dissolution, 0.5 mL of acryloyl chloride was added dropwise, and the reaction was carried out at 65 °C for 3 h. After the reaction, 200 mL of deionized water was added to the mixed solution to precipitate the precipitated product. After stirring for 5 hours, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, add 200 mL of deionized water to separate out the precipitated product, stir for 5 hours, let stand for 15 minutes, remove the aqueous solution, and dissolve the precipitate in acetone, After repeating the above process of adding deionized water, stirring, standing, removing water, and dissolving the precipitate in acetone for 5 times, at 25 °C, dialyzed in ethanol for 8 h to remove residual acryloyl chlo...

Embodiment 3

[0054] Preparation of acrylated-octanoylated-hydroxypropyl cellulose ester liquid crystal: 20 g of hydroxypropyl cellulose (M W = 80,000, purchased from Aldrich Company) and dissolved in acetone solution; after complete dissolution, 10 mL of acryloyl chloride was added dropwise to it, and the reaction was carried out at 45 °C for 6 h. After the reaction, 200 mL of deionized water was added to the mixed solution to precipitate the product, and stirred for 5 h Then, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, then add 200 mL of deionized water to precipitate the precipitated product, stir for 5 h, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitate in acetone, repeat The above process of adding deionized water, stirring, standing, removing water, and dissolving the precipitate in acetone for 3 times, at 25 ° C, dialyzed in tetrahydrofuran for 8 h to remove residual acryloyl chloride, and dried; t...

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Abstract

The invention belongs to the field of biological materials and discloses a surface-heparinized cellulose ester liquid crystal material and a preparation method and application thereof. The preparation method of the liquid crystal material comprises the following steps of: (1) preparation of acryloyl-octanoyl-hydroxy propyl cellulose ester liquid crystal: dissolving hydroxy propyl cellulose into an acetone solution, adding acryloyl chloride and reacting; after the reaction is over, cleaning the obtained mixed solution for 3-5 times, and dialyzing and drying; dissolving the obtained product in acetone, dropwise adding octanoyl chloride and reacting; and cleaning, dialyzing and drying to obtain acryloyl-octanoyl-hydroxy propyl cellulose ester; and (2) preparation of surface-heparinized cellulose ester liquid crystal material: dissolving the acryloyl-octanoyl-hydroxy propyl cellulose ester liquid crystal in tetrahydrofuran, fetching the solution to form a film, then adding a sodium hydroxide solution of heparin sodium, reacting and cleaning to obtain the surface-heparinized cellulose ester liquid crystal material.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a surface heparinized cellulose ester liquid crystal material and a preparation method and application thereof. Background technique [0002] For medical devices that come into contact with blood, it is required that when they come into contact with blood, they will not cause coagulation and platelet adhesion and aggregation, and have no adverse effects such as hemolysis that destroys the formed components in the blood, that is, they have blood compatibility. The blood compatibility of medical devices is directly related to the effect of their clinical use. For decades, the development of novel thrombus-free biomaterials has been an extremely challenging topic in the field of biomaterials and a core technical issue for medical devices. [0003] Liquid crystal (LC) is an intermediate phase between liquid phase and solid phase, which not only has the fluidity and co...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08L1/32C08B13/00C09K19/38
Inventor 屠美查振刚曾戎赵巨鹏赵剑豪
Owner JINAN UNIVERSITY
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