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Composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and preparation method of composite antibacterial agent

A technology of organosilicon quaternary ammonium salt and compound antibacterial agent, which is applied in the field of biomedicine, can solve the problems of difficult treatment of infectious diseases, serious pathogenic microorganisms, and high mortality rate, and achieves good sterilization and repair performance, safe and antibacterial, and avoids side effects. Effect

Active Publication Date: 2013-09-11
陈美儿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the widespread use of antibiotics, bacteria have gradually adapted and developed resistance to them, especially the excessive use of antibiotics in feed additives and food preservatives, as well as a large number of inappropriate use of antibiotics in medical practice. Use, such as free purchase of long-term antibiotics, clinical irrational use of antibiotics, and even "abuse" are very common, leading to the emergence of a large number of resistant strains of various antibiotics, leading to more and more cures for certain infectious diseases, The more difficult it is to treat, the higher the fatality rate; the drug resistance of pathogenic microorganisms is becoming more and more serious, and the emergence of "super bacteria" makes the treatment of infectious diseases more difficult, which has aroused the concern and anxiety of the medical community, society and the government. The World Health Organization The organization set the theme for World Health Day 2011 as: "Fighting Drug Resistance - No Action Today, No Medicines Tomorrow"

Method used

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  • Composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and preparation method of composite antibacterial agent
  • Composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and preparation method of composite antibacterial agent
  • Composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and preparation method of composite antibacterial agent

Examples

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Effect test

no. 1 example

[0047] Illustrate with making composite antibacterial gel for vagina, the raw material formula of composite antibacterial gel for vagina includes following weight components:

[0048] Chitosan 5%; silicone quaternary ammonium salt 0.5%; chlorhexidine acetate 0.5%; lactic acid about 3%; the balance is purified water. Wherein, chitosan is medical chitosan, the same below.

[0049] When preparing, include the following steps:

[0050] Step 1, under the condition of GMP purification plant, first add the purified water and chitosan after weighing in the vacuum stirring container to mix to obtain the solution, then turn on the mixer of the vacuum stirring container to slowly stir the solution, and open the vacuum stirring container at the same time The solution was boiled with a jacketed heater and sterilized at 100°C for 15 minutes.

[0051] In the first step, when stirring slowly, the rotational speed of the stirrer is 10-25 rpm.

[0052] Step 2, stop heating, reduce the temper...

no. 2 example

[0058] Illustrate with making vaginal antibacterial douche, the raw material formula of vaginal antibacterial douche includes following weight components:

[0059] Chitosan 0.5%; organosilicon quaternary ammonium salt 0.1%; chlorhexidine acetate 0.5%; lactic acid about 0.3%; the balance is purified water.

[0060] When preparing, include the following steps:

[0061] Step 1, under the condition of GMP purification plant, first add the purified water and chitosan after weighing in the vacuum stirring container to mix to obtain the solution, then turn on the mixer of the vacuum stirring container to slowly stir the solution, and open the vacuum stirring container at the same time The interlayer heater boils the solution, and sterilizes it at 100°C for 15 minutes;

[0062] Step 2, stop heating, reduce the temperature of the solution to about 70°C, speed up the stirring speed of the mixer, add the weighed chlorhexidine acetate into the vacuum stirring container and stir to dissol...

no. 3 example

[0068] Illustrate with making chronic rhinitis antibacterial spray lotion, the raw material formula of chronic rhinitis antibacterial spray lotion comprises following weight components:

[0069] Chitosan 0.5%; organosilicon quaternary ammonium salt 0.1%; polyhexamethyleneguanidine 0.2%; acetic acid about 3%; the balance is purified water.

[0070] When preparing, include the following steps:

[0071] Step 1, under the condition of GMP purification plant, first add the purified water and chitosan after weighing in the vacuum stirring container to mix to obtain the solution, then turn on the mixer of the vacuum stirring container to slowly stir the solution, and open the vacuum stirring container at the same time The interlayer heater boils the solution, and sterilizes it at 100°C for 15 minutes;

[0072] Step 2, stop heating, reduce the temperature of the solution to about 70°C, speed up the stirring speed of the mixer, add the weighed polyhexamethylene guanidine into the vacu...

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Abstract

The invention discloses a composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and a preparation method of the composite antibacterial agent. The composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt comprises the following raw materials by weight percent: 0.3-0.6% of chitosan, 0.1-2% of organosilicone quaternary ammonium salt, 0.02-0.5% of antibacterial auxiliary, 2-6% of PH adjustor and the balance of purified water. The composite antibacterial agent is prepared by using medical chitosan and organosilicone quaternary ammonium salt as the main components and the antibacterial adjuvant as the adjuvant, the biocompatibility of the original materials are maintained; and the polymeric material is good in bactericidal performance, quick-acting, long-acting, broad spectrum, stable and safe in antibacterial and anti-drug-resistant effect; the composite antibacterial agent can be used for preventing and treating common diseases such as chronic rhinitis, canker sore, colpitis, cervicitis, haemorrhoids, burn scald and trauma, the therapeutic biological antibacterial agent is provided with excellent dual-function of sterilizing and repairing. The composite antibacterial agent disclosed by the invention is good in sterilizing and repairing performance and wide in applicable range.

Description

technical field [0001] The invention relates to a compound antibacterial agent of chitosan and organosilicon quaternary ammonium salt and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] The discovery of antibiotics is of great significance in the history of human medicine. Its use has saved countless lives and increased human life expectancy by more than ten years. However, with the widespread use of antibiotics, bacteria have gradually adapted and developed resistance to them, especially the excessive use of antibiotics in feed additives and food preservatives, as well as a large number of inappropriate use of antibiotics in medical practice. Use, such as free purchase of long-term antibiotics, clinical irrational use of antibiotics, and even "abuse" are very common, leading to the emergence of a large number of resistant strains of various antibiotics, leading to more and more cures for certain infectious diseases, The mo...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P31/04A61P29/00A61P15/02A61P15/00A61P9/14A61P11/02A61P1/02A61P17/02A61K31/695
Inventor 陈美儿刘良韡刘洋熙
Owner 陈美儿
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