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Vaccine for immunizing sheep for producing twins and preparation method thereof

A technology of bisporin and vaccines, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of not adapting to the level of productivity, expensive raw materials, unstable effects, etc. Achieve the effects of increasing the double lamb rate, accelerating maturation and excretion, and strengthening the negative feedback function

Inactive Publication Date: 2013-09-04
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the problem with the twin vaccine of Australia's "Fecundin" is that the raw materials are expensive, and it needs to order from abroad, spend foreign exchange, and the cost is high, which is not suitable for the current productivity level in my country (Wang Lizhi. Application technology of immunized fecundin [J]. China Agronomy Bulletin, 1992, (04): 39-41. )
The results showed that different antigen types of dilamsin can significantly increase the lambing rate of sheep, but the effect is not stable, and the effect of improving lambing is different in different experiments. The same sheep is used in the same place for two consecutive years. The same antigen There are differences in the effects of different preparations, different breeds of sheep using the same antigen preparation or the same breed of sheep using the same antigen preparation in different regions (Jiao Shuo, Feng Ruilin, Sun Xiaoping. The application effect of domestic steroidal antigen bilamin[J]. Livestock Journal of Ecology, 2006, (06): 247-250. )

Method used

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  • Vaccine for immunizing sheep for producing twins and preparation method thereof
  • Vaccine for immunizing sheep for producing twins and preparation method thereof
  • Vaccine for immunizing sheep for producing twins and preparation method thereof

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specific Embodiment approach

[0015] 1. Synthesis of testosterone-3-carboxymethyl oxime-bovine serum albumin antigen

[0016] 1.1 Synthesis and detection of carboxymethylhydroxylamine hydrochloride

[0017] (1) Synthetic route:

[0018] (CH 3 ) 2 C=N-OH + BrCH 2 COOH → (CH 3 ) 2 C=NOCH 2 COOH

[0019] Acetone oxime Bromoacetic acid Acetone oxime acetate

[0020] 2(CH 3 ) 2 C=NOCH 2 COOH + 2H 2 O + HCl → (H 2 NOCH 2 COOH) 2 HCl

[0021] Acetone oxime acetate Carboxymethylhydroxylamine hydrochloride

[0022] (2), synthesis steps:

[0023] Solution A: Mix 122.4g of bromoacetic acid with 200g of crushed ice, then add 100ml of 40% sodium hydroxide

[0024] Solution B: Put 58.4g of acetone oxime in an ice-water bath, add 100ml of 40% sodium hydroxide (T≤20°C when adding alkali)

[0025] After it is completely dissolved, mix the AB solution (the mixture should be obviously alkaline). Let the mixed solution drop by drop through a straight condenser tube heated with water vapor (the reaction t...

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Abstract

The invention relates to a vaccine for immunizing sheep for producing twins and preparation method thereof. The sheep twining element vaccine comprises an antigen of testosterone-3-carboxymethyl oxime-bovine serum albumin. In the real application, the sheep twining element vaccine also comprises a DEAE-glucan as adjuvant or 206 adjuvant. When the DEAE-glucan is used as adjuvant, the concentration of water dosage form antigen in the vaccine is 1.5 mg / ml, and the concentration of DEAE-glucan is 0.05 g / ml; when the 206 adjuvant is used, the concentration of the oil dosage form antigen in the vaccine is 1.5 mg / ml, and the volume ratio between the oil dosage form antigen and the 206 adjuvant is 46:54. Experiments of application for many years expresses that the ovulation number of the ewe is increased by 30-50% by using the vaccine according to the invention, and the lambing rate is increased by 20-30%.

Description

technical field [0001] The invention relates to a vaccine capable of making sheep produce twin lambs and a preparation method thereof, in particular to a vaccine for immunizing sheep to produce twin lambs and a preparation method thereof. Background technique [0002] With the development of economy and society, people's living standards are improving day by day, and the demand for mutton and plush products is constantly increasing. However, common sheep breeds are all single-born breeding, resulting in relatively low sheep production efficiency. How to improve the production performance of sheep is a problem that animal husbandry and veterinary scientists have been paying attention to, and it is also a need to meet the needs of domestic and foreign mutton and plush markets. Fecundity is an important economic indicator in sheep production efficiency, and lambing rate is one of the main indicators for evaluating sheep fecundity (Guo Xian. Research and Application of Inhibin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/385A61K47/48A61K9/19A61P15/08A61K39/00
Inventor 冯瑞林岳耀敬杨博辉郭健刘建斌孙晓萍郭婷婷焦硕王利智
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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