Method for constructing animal model of hyperuricemia induced renal interstitial fibrosis
A technology for renal interstitial fibrosis and hyperuricemia, which is applied in the directions of active ingredients of heterocyclic compounds, pharmaceutical formulations, plant raw materials, etc., can solve problems such as disease deterioration, treatment delay, lack of systematic understanding of the disease, and standardized diagnosis and treatment methods.
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[0080] Embodiment 1, the establishment of the Wistar rat animal model of hyperuricemia-induced renal interstitial fibrosis
[0081] 1. Experimental grouping with diet plan
[0082] After adapting to feeding for one week, 60 male Wistar rats (6 weeks old) were randomly divided into 2 groups according to body weight, namely normal group and high uric acid group, 30 rats in each group.
[0083] Rats in the high uric acid group were all fed with yeast feed containing 10% yeast powder, and fed with adenine aqueous solution with a concentration of 20g / L according to the dosage of 100mg adenine / (kg body weight·d); rats in the normal group were fed with Rats were fed with ordinary pellets and given the same volume of distilled water for gavage.
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