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Traditional Chinese medicinal composition for controlling chronic hepatopathy, and uses thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for the prevention and treatment of chronic liver disease, can solve the problems such as undiscovered literature reports, achieve the effects of reducing the collagen content of liver tissue, reducing the degree of liver damage, and improving liver function

Inactive Publication Date: 2014-12-31
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it has been verified that there is no patent publication related to the content of this application, and no literature reports on the application of the same traditional Chinese medicine prescription in the field of liver disease as this patent application have been found. Therefore, the content claimed in this patent application is the first discovery, with novelty and creativity

Method used

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  • Traditional Chinese medicinal composition for controlling chronic hepatopathy, and uses thereof
  • Traditional Chinese medicinal composition for controlling chronic hepatopathy, and uses thereof
  • Traditional Chinese medicinal composition for controlling chronic hepatopathy, and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The rat liver fibrosis model induced by DMN is used to prove that the traditional Chinese medicine composition of the present invention can significantly inhibit the progress of liver fibrosis and the formation of liver cirrhosis.

[0021] 1. Materials and methods:

[0022] 1.1 Animals

[0023] 44 Wistar male rats, clean grade, weighing 150-170 g, were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences, license number: SCXK (Shanghai) 2003-0003. Raised, modeled and observed in the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, free to eat and drink.

[0024] 1.2 Main reagents and equipment

[0025] Dimethylnitrosamine (Dimethylnitrosamine, DMN) and hydroxyproline (hydroxyproline, Hyp) standard products, Tokyo Kasei Kogyo Co., Ltd.; Olympus IX70 optical microscope was purchased from Olympus.

[0026] 1.3 medicine (using Chinese medicine composition of the present invention)

[0027] Sanleng, Curcuma off...

Embodiment 2

[0049] Using CCl 4 The induced mouse liver fibrosis model proves that the traditional Chinese medicine composition of the present invention can significantly inhibit the progression of liver fibrosis and the formation of liver cirrhosis.

[0050] 1. Materials and methods:

[0051] 1.1 Animals

[0052] Thirty-six male C57BL / 6 mice, 8 weeks old, were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. Raised, modeled and observed in the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, free to eat and drink.

[0053] 1.2 Main reagents and equipment

[0054] Carbon tetrachloride (CCl 4 ) was purchased from Sinopharm Group, the standard product of hydroxyproline (Hyp) was purchased from Tokyo Chemical Industry Co., Ltd.; the Olympus IX70 optical microscope was purchased from Olympus Company.

[0055] 1.3 medicine (same as embodiment 1)

[0056] 1.4 Preparation of liver fibrosis model

[0057] 10%CCl 4 ...

Embodiment 3

[0077] The preparation of embodiment 3 tablet

[0078] Weigh the following raw materials: Sanleng 9g, Curcuma 9g, Magnolia officinalis 6g, Cornus officinalis 6g, Coptidis 1.5g, Muxiang 3g, Dried ginger 3g, Pinellia chinensis 3g, Turtle shell 6g, make coarse powder, 15 times each time Soak in a measured amount of water for 0.5 hour, heat and reflux for extraction twice, concentrate the filtrate to an extract, and dry it in vacuum to obtain a dry extract; add appropriate amount of auxiliary materials to obtain a tablet. Each tablet contains 90 mg of the traditional Chinese medicine composition. Usage: 5 tablets each time, 3 times a day, 7 days a week, 12 weeks as a course of treatment.

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating the chronic hepatopathy. The composition is prepared through mainly using the following raw medicines, by weight, 9-30 parts of Rhizoma Sparganii, 9-30 parts of Rhizoma Curcumae, 6-30 parts of cortex magnoliae officinalis, 6-30 parts of Cornus officinalis, 1.5-15 parts of Rhizoma Coptidis, 3-30 parts of Radix Aucklandiae, 3-30 parts of dry ginger, 3-15 parts of processed Pinellia Tuber, and 6-30 parts of turtle shell. The medicinal composition having effective hepatic fibrosis and hepatic injury resistances is obtained through adopting traditional Chinese medicines having blood circulation invigorating, blood stasis dispersing, phlegm reducing, hardness softening and bind dissipating effects. Results of classic animal model experiments and verifications prove that the traditional Chinese medicinal composition can substantially reduce the content of collagens in the hepatic tissues of model rats, mitigates the hepatic fibrosis and hepatic injury degrees, and effectively prevents the development of the hepatic fibrosis and promotes the reversion of the hepatic fibrosis. The traditional Chinese medicinal composition can be used for treating and preventing all kinds of chronic hepatitis, hepatic fibrosis, hepatic cirrhosis, hepatic tumors and the like. The traditional Chinese medicinal composition can be processed to prepare oral solid preparations comprising a tablet, a granule, a capsule and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating chronic liver disease and its application. Background technique [0002] Liver cirrhosis is one of the common diseases and leading causes of death in my country. my country is an area with a high incidence of hepatitis B. There are 30 million patients with chronic hepatitis B, and about 30% of them develop into liver cirrhosis. Evidence has shown that liver fibrosis and early liver cirrhosis are reversible. Blocking or reversing liver fibrosis is an important goal in the treatment of chronic liver diseases, but there is no FDA-approved chemical or biological agent against liver fibrosis in clinical application . [0003] In recent years, under the guidance of the overall concept of traditional Chinese medicine (system theory method), the co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/16
Inventor 刘平张笑宁冰冰慕永平孙明瑜陈高峰刘佳刘成海胡义扬徐列明
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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