Cone-beam X-ray luminescence computed tomography method

Abstract

The invention discloses a cone-beam X-ray luminescence computed tomography method based on a simplified ball harmonic wave-diffusion approximation model and solves the problem of fast and accurate imaging for achieving fluorescence image reconstruction based on a diffusion approximation equation or by aid of the traditional X-ray computed tomography technology in the prior art. The cone-beam X-ray luminescence computed tomography method is characterized in that an objective function is constructed on the basis of the simplified ball harmonic wave-diffusion approximation model and a sparse regularization method, and the objective function is solved in a half greedy algorithm to achieve fast and accurate reconstruction of in-vivo fluorescence nano-particle probes. The cone-beam X-ray luminescence computed tomography method specifically includes steps: data collection and preprocessing, living body anatomical structure reconstruction, body surface fluorescence data acquisition, forward light transmission model construction, sparse regularization objective function construction, objective function optimization solution and three-dimensional reconstruction result display. The cone-beam X-ray luminescence computed tomography method has the advantages of being capable of achieving accurate, fast and high-resolution position and concentration distribution reconstruction of the in-vivo fluorescence nano-particle probes, and being capable of being applied to the field of X-ray fluorescence computed tomography.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and further relates to a cone-beam X-ray luminescence tomography method based on a simplified spherical harmonic-diffusion approximation model in the technical field of optical molecular imaging. This method can be applied to small animal experiments such as tumor detection, new drug development and efficacy evaluation to obtain the intensity distribution information of the target. Background technique [0002] X-ray luminescence tomography is an emerging optical molecular imaging technology. It uses X-rays to excite fluorescent nanoparticle probes that mark specific cells in small animals to emit near-infrared fluorescence; then, the emitted light is collected by a high-sensitivity CCD camera. near-infrared light; finally, near-infrared optical tomography was used to reconstruct the distribution of fluorescent nanoparticle probes in small animals. Due to the use of X-rays as the excitat...

AI Technical Summary

Problems solved by technology

However, the diffusion approximation equation can only describe the transport process of emitted fluorescence in tissues with high scattering properties

For complex organisms with multiple scattering properties, including biological tissues with low scattering or weak scattering properties, the diffusion approximation equation will not be able to accurately describe the transmission process of emitted fluorescence, so it will not be able to provide accurate three-dimensional imaging results

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