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2-bromine-4,6-dichloroaniline preparation method

A technology of dichloroaniline and hydrobromic acid, applied in the field of 2-bromo-4, can solve problems such as high cost and difficult industrial implementation, and achieve the effects of easy industrial implementation, no three wastes, and low cost

Active Publication Date: 2013-07-31
INSIGHT HIGH TECH JIANGSU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method can overcome the problems of high cost and difficult industrial implementation in the existing methods, and is a preparation method with low production cost, simple operation and industrial production value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Preparation of 2-bromo-4,6-dichloroaniline

[0022] Add 32.4g (0.2mol) of 2,4-dichloroaniline, 500ml of water, 33.8g (0.2mol) of 48% hydrobromic acid into a 1000ml reaction bottle, stir and heat, keep at 10-50℃ and add hydrogen peroxide dropwise , kept at 10-50°C and reacted for 10 hours, stopped the reaction, stirred and cooled down, solid precipitated, filtered with suction to obtain off-white solid powder, dried to obtain 47.0g, content: 99.7%, yield: 97.8%.

Embodiment 2

[0023] Example 2: Preparation of 2-bromo-4,6-dichloroaniline

[0024] Add 32.4g (0.2mol) of 2,4-dichloroaniline, 500ml of water, 33.8g (0.2mol) of 48% hydrobromic acid into a 1000ml reaction bottle, stir and heat, keep at 10-50℃ and add hydrogen peroxide dropwise , kept at 10-50°C and reacted for 10 hours, stopped the reaction, stirred and cooled down, solid precipitated, filtered with suction to obtain off-white solid powder, dried to obtain 47.1g, content: 99.8%, yield: 98.1%.

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PUM

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Abstract

The invention relates to a preparation method for a medicine KCNQ potassium channel conditioning agent critical material 2-bromine-4,6-dichloroaniline. According to the invention, 2,4-dichloroaniline is taken as a raw materials, and is subjected to NBS (N-bromosuccinimide) bromination to obtain a target object, and the preparation method of the invention has the advantages of low preparation method and simple operation, and has industrial production value.

Description

technical field [0001] The present invention relates to a preparation method of a compound, in particular to a preparation method of 2-bromo-4,6-dichloroaniline (formula II), a key raw material of the KCNQ potassium ion channel regulator (formula I). Background technique [0002] Ion channels are proteins that control the entry and exit of ions into and out of cells. They are widely present on various cell membranes and have selective permeability. It is the basis for the excitation of cell membranes in nerves, muscles and other tissues, as well as the basis for bioelectrical activity. The opening and closing of ion channels causes nerve cells to generate electrical nerve impulses. Scientists already know that ion channels are involved in a variety of diseases, from epilepsy to Parkinson's disease, and are the pathways through which toxins and many drugs work. [0003] Potassium ion channels are by far the most types of ion channels, they are widely distributed in skeletal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C211/52C07C209/74
Inventor 胡圣祥吴国平李冬梅孙贤袁忠华黄帅杰
Owner INSIGHT HIGH TECH JIANGSU CO LTD
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