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Periplaneta americana extract and its preparation method and use

An extract technology of Periplaneta americana, applied in the field of medicine, can solve problems such as delay in treatment, inability to continue treatment, and resistance, etc., and achieve the effect of no fishy smell, good clinical promotion and application value, and stable and reliable quality

Active Publication Date: 2013-07-31
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some patients have resistance during use, and even experience nausea, vomiting and other gastrointestinal discomforts, resulting in inability to continue treatment and delaying the condition

Method used

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  • Periplaneta americana extract and its preparation method and use
  • Periplaneta americana extract and its preparation method and use
  • Periplaneta americana extract and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 40kg of fresh worms of Periplaneta americana, add acetone to heat and reflux 4 times, add 3 times the amount each time, reflux for 1 hour each time, wave off the acetone, add water to decoct and extract 3 times, add water 5 times the volume of the medicinal material each time , decocted and extracted for 1 hour each time, filtered; the filtrate was concentrated under reduced pressure at 70°C to a relative density of 1.08 (measured at 60°C), added ethanol until the alcohol content reached 75%, stood at 0°C for 12 hours, and filtered; the filtrate Recover ethanol under normal pressure until there is no alcohol smell, add water until each milliliter is equivalent to 1 gram of crude drug, and filter; the filtrate passes through a D101 macroporous adsorption resin column, rinses the resin column with pure water, and collects the effluent until the ninhydrin reaction in the effluent Negative; the effluent passes through the polyamide column, rinses the resin column with...

Embodiment 2

[0042] Weigh 30kg of dried Periplaneta americana, add acetone to heat and reflux 3 times, add 4 times the amount each time, reflux for 60 minutes each time, wave off the acetone, add water to decoct and extract 3 times, add water 10 times the volume of the medicinal material each time , decocted and extracted for 1 hour each time, filtered; the filtrate was concentrated under reduced pressure at 75°C to a relative density of 1.05 (measured at 60°C), added ethanol until the alcohol content reached 80%, stood at 4°C for 12 hours, and filtered; the filtrate Recover ethanol under reduced pressure until there is no alcohol smell, add water until each milliliter is equivalent to 1 gram of crude drug, and filter; the filtrate passes through HPD100 macroporous adsorption resin column, rinses the resin column with pure water, and collects the effluent until the ninhydrin reaction in the effluent Negative; the effluent passes through the polyamide column, rinses the resin column with pu...

Embodiment 3

[0044] Weigh 25kg of dried Periplaneta americana, add acetone, heat and reflux 3 times, add 3 times the amount each time, reflux for 30 minutes each time, wave off the acetone, add water to decoct and extract 2 times, add water 20 times the volume of the medicinal material each time , decocted and extracted for 2 hours each time, filtered; the filtrate was concentrated under reduced pressure at 68°C to a relative density of 1.25 (measured at 60°C), added ethanol until the alcohol content reached 55%, stood at 25°C for 24 hours, and filtered; the filtrate Recover ethanol under reduced pressure until there is no alcohol smell, add water until each milliliter is equivalent to 2 grams of crude drug, and centrifuge; the supernatant passes through the AB-8 macroporous adsorption resin column, rinses the resin column with pure water, and collects the effluent until the effluent is indene The triketone reaction was negative; the effluent passed through the polyamide column, and the re...

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Abstract

The invention discloses periplaneta americana extract and its preparation method and use. The preparation method comprises the following steps of carrying out acetone backflow, water extraction and condensation, adding ethanol into the concentrate, carrying out ethanol recovery to obtain the filtrate without ethanol, treating the filtrate without ethanol by an adsorption resin column, collecting the eluant until eluant ninhydrin reaction is negative, by a polyamide column, collecting the eluant until eluant ninhydrin reaction is negative, and carrying out condensation and drying. The invention also discloses the novel use of the periplaneta americana extract. The preparation method overcomes the defects of the traditional preparation method and has a high application value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of an extract of Periplaneta americana. Background technique [0002] Periplaneta americana (Periplaneta americana) is an insect belonging to the genus Periplaneta in the subclass Insecta Pterosae, Blatella order, Blattedae, commonly known as "cockroach". Taste: salty, cold; Cure: blood stasis syndrome with hard cold and heat, broken accumulation, closed throat, internal cold without seeds". "Cockroach" is its common name first seen in "Compendium of Materia Medica Supplements", and it is also called Shijiang and slippery insect; different places have its own name, such as: stealing oil woman, tea woman, stove ant, etc. Blattidae (Blattidae) is a huge insect family that has existed on the earth for 320 million years. It is a creature that appeared in the same era as dinosaurs. Undoubtedly, it is one of the most vigorous, oldest, and most successful insect ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P17/02C12N5/071A61K35/63
CPCA61K35/64A61K35/63A61P17/02
Inventor 耿福能马秀英吴桃清
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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