Preparation method of electrochemical transducer capable of rapidly and selectively detecting azithromycin

An azithromycin and electrochemical technology, applied in the field of preparation of electrochemical sensors, can solve the problems of detection range, sensitivity, selectivity, and stability to be further improved, and achieve the effect of low preparation cost, high sensitivity, and good stability

Inactive Publication Date: 2015-02-18
JIANGXI SCI & TECH NORMAL UNIV
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Problems solved by technology

However, the electrochemical oxidation detection of azithromycin and the residues of azithromycin in livestock by using the composite electrode of graphene oxide and multi-walled carbon nanotubes has not been reported, and the detection range, sensitivity, selectivity and stability of the current electrochemical detection method for azithromycin are still to be determined. further improvement

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  • Preparation method of electrochemical transducer capable of rapidly and selectively detecting azithromycin
  • Preparation method of electrochemical transducer capable of rapidly and selectively detecting azithromycin
  • Preparation method of electrochemical transducer capable of rapidly and selectively detecting azithromycin

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Embodiment Construction

[0015] A method for preparing an electrochemical sensor for rapid and selective determination of the content of azithromycin in different dosage forms of azithromycin medicines and the residual azithromycin in livestock by using a composite electrode of graphene oxide and multi-walled carbon nanotubes, comprising the following steps:

[0016] 1. Preparation of composite materials: 0.3 mg of graphene oxide and 25 mg of multi-walled carbon nanotubes with a solid content of 4% were prepared into 1 mL of mixture with water, ultrasonicated for 3 hours, then stirred for 12 hours, mixed evenly to obtain a uniform and stable dispersion mixed solution;

[0017] 2. Preparation of the composite electrode: 5 μL of the mixed solution was drip-coated on the surface of the glassy carbon electrode, and then dried at 60°C to obtain a composite electrode of graphene oxide and multi-walled carbon nanotubes.

[0018] Electrochemical response of azithromycin: in a sodium bicarbonate solution (0.05...

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Abstract

The invention discloses a preparation method of an electrochemical transducer capable of rapidly and selectively detecting azithromycin. The preparation method comprises the following steps of: mixing graphene oxide and a multi-wall carbon nanotube according to a certain proportion by utilizing a blending method, thus preparing an electrode compounded with the graphene oxide and the multi-wall carbon nanotube; and carrying out electrochemical detection on the azithromycin in a solution taking sodium bicarbonate (0.05 mol / L) as a supporting electrolyte, wherein the combined electrode can display good electrocatalytic activity on the azithromycin. The electrode can realize efficient, sensitive and selective detection on the azithromycin, and can be successfully applied for measuring azithromycin content in different azithromycin agents and azithromycin remained in livestock bodies such as pigs, cattles, sheep, chickens and ducks. The electrochemical transducer prepared by the preparation method provided by the invention has the advantages that an electrode material is easy to prepare, the cost is low, the operation is simple and convenient, the preparation method is rapid and efficient, the sensitivity is high, and the like.

Description

technical field [0001] The invention belongs to the field of electrochemical sensors, and relates to a preparation method of an electrochemical sensor for rapid and selective detection of azithromycin. Background technique [0002] Azithromycin is a macrolide antibiotic, a nitrogen-containing 15-membered ring erythromycin derivative obtained from erythromycin oxime through Beckmann rearrangement, reduction, N-methylation and other reactions. In recent years, the abuse of antibiotics and the residues of antibiotics in food have aroused widespread concern. Azithromycin, as a new generation of macrolide antibiotics with the fastest sales growth, is widely used in In the livestock, poultry and aquaculture industries, the antibiotic resistance of animal-derived pathogens caused by it has also brought harm to human, animal health and the environment. A variety of assay methods for azithromycin have been established at present, and the widely used method is mainly chromatography, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/28
Inventor 段学民张凯鑫徐景坤卢丽敏张龙胡杜芬文阳平
Owner JIANGXI SCI & TECH NORMAL UNIV
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