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Surface patterning high-strength and high-toughness hybrid hydrogel membrane and preparation method thereof

A technology of surface patterning and hybrid gel, applied in the field of functional materials and biomaterials, can solve the problems such as difficult to control uniform thickness of hydrogel film, low strength and toughness of hydrogel, difficult surface patterning of hydrogel, etc. To achieve the effect of good application prospect, low cost, simple preparation method and process

Active Publication Date: 2015-04-22
嘉兴智德睿控新能源有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of the prior art, the present invention intends to solve the problems of difficult surface patterning of hydrogels, low strength and toughness of hydrogels, difficulty in controlling uniform thickness of hydrogel films, etc.
[0008] The technical solution of the present invention to solve the problems of difficult surface patterning of the above-mentioned hydrogel, low strength and toughness of the hydrogel, and difficulty in controlling the uniform thickness of the hydrogel film is to design a hybrid gel film with high strength and high toughness with surface patterning

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1. A high-strength and high-toughness gel film patterned with narrow straight stripes on the surface and its preparation method

[0020] a) successively wash the silicon wafer patterned with narrow straight stripes with dilute hydrochloric acid, absolute ethanol and deionized water, and then vacuum-dry at 60° C. for 24 hours to obtain a dried patterned silicon wafer;

[0021] b) Weigh 15g of isopropylacrylamide, 0.5g of sodium alginate, and ethylene glycol dimethacrylate with a mass percentage of 0.03% of isopropylacrylamide, dissolve them in 100ml of deionized water together, stir to dissolve evenly, and then add The strengthening agent nano-hydroxyapatite with 1% by mass of isopropylacrylamide is uniformly dispersed by ultrasonic, and then ammonium persulfate with 5% by mass of isopropylacrylamide and sulfurous acid with 5% by mass of isopropylacrylamide are added Sodium hydrogen and tetramethylethylenediamine with a mass percentage of 0.01% isopropylacrylamid...

Embodiment 2

[0023] Example 2. A wide vertical stripe patterned high-strength and high-toughness gel film and its preparation method

[0024] a) Washing the silicon wafer patterned with wide vertical stripes with dilute hydrochloric acid, absolute ethanol and deionized water successively, and then drying in vacuum at 80° C. for 8 hours to obtain a silicon wafer patterned with wide vertical stripes after drying;

[0025]b) Weigh 5g of diacetone acrylamide, 2g of sodium alginate, and divinylbenzene with a mass percentage of 0.15% of diacetone acrylamide, dissolve them in 50ml of deionized water, stir and dissolve evenly, and then add 200% of diacetone acrylamide by mass % of reinforcing agent nano-silica, after ultrasonic dispersion is uniform, add diacetone acrylamide mass percentage 5% ammonium persulfate, diacetone acrylamide mass percentage 5% sodium bisulfite and diacetone acrylamide mass percentage 0.1% After stirring and dispersing evenly, pour the solution into the patterned silicon ...

Embodiment 3

[0027] Example 3. A cylindrical surface patterned high-strength and high-toughness gel film and its preparation method

[0028] a) successively washing the cylindrical patterned silicon wafer with dilute hydrochloric acid, absolute ethanol and deionized water, and then vacuum drying at 80° C. for 8 hours to obtain a dried patterned silicon wafer;

[0029] b) Weigh 15g of acrylamide, 0.5g of sodium alginate, and ethylene glycol dimethacrylate with a mass percentage of 0.03% of acrylamide, dissolve them together in 100ml of deionized water, stir to dissolve evenly, and then add 1% of acrylamide by mass The strengthening agent nano-titanium dioxide, after ultrasonic dispersion, add ammonium persulfate of 0.1% by mass of acrylamide, sodium bisulfite of 0.1% by mass of acrylamide and tetramethylethylenediamine of 0.01% by mass of acrylamide, and stir After the dispersion is uniform, immediately pour the solution into the patterned silicon wafer treated in step a), scrape it with a ...

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Abstract

With the continuous development of tissue engineering, a surface patterning technology is concerned by people more and more and widely applied; and a micro-patterning technology is already used for accurately controlling the position and form of a cell and the co-culture of multiple cells, but a micro-pattern is more difficult to be directly constructed on the surface of hydrogel with good biocompatibility. The high-elasticity and high-toughness patterning hydrogel membrane is prepared on a patterning silicon slice base body by taking sodium alginate as a high-molecular framework, acrylamide and a derivative thereof as polymerization monomers, divinylbenzene, N,N'-methylene bisacrylamide or ethylene glycol dimethacrylate as chemical cross-linking agents and a metal salt water solution as an ionic cross-linking agent and adding inorganic nanoparticles as strengthening agents. The preparation method disclosed by the invention has the advantages of good controllability, simple process, low cost, good material biocompatibility, and the like; and the patterning hydrogel membrane disclosed by the invention is hopeful to be applied to the fields of stem cell culture, tissue regeneration, and the like.

Description

technical field [0001] The invention relates to a surface-patterned high-strength and high-toughness hybrid gel film and a preparation method thereof, belonging to the field of functional materials and biological materials. Background technique [0002] In recent years, with the development of tissue engineering and regenerative medicine, more and more attention has been paid to the surface modification of materials and cell adhesion. Human tissue can be regarded as a complex of cells and extracellular matrix. If we can use new biomaterials imitating extracellular matrix to construct a certain life-like environment, and cultivate cells on its surface or inside, we can use it in vitro Bionic means to study important life activities inside the body. To construct complexes of cells and biomaterials in vitro, it is necessary to understand many basic scientific issues in the interaction between cells and biomaterials, one of the most critical issues is the adhesion mechanism of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08J3/075C08J3/24C08L51/02C08F251/00C08K3/36C08K3/22C08K3/32C08K3/34C08K7/00C08K3/04C08K3/26
Inventor 赵孔银冯灵智阚伯红崔文葵吴寻霖任倩
Owner 嘉兴智德睿控新能源有限公司
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