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Method for extracting puerarin

A puerarin and extraction technology, which is applied in the production of bulk chemicals and organic chemistry, can solve the problems of the loss of active components of puerarin, high cost, and puerarin residue, so as to save energy and labor costs and prevent environmental pollution , the effect of preventing the poisoning of the human body

Inactive Publication Date: 2013-07-17
湖北万松堂大健康医药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the macroporous adsorption resin method is more commonly used, which can extract puerarin with higher purity, but it is easy to cause the loss of active components of puerarin, which affects the medicinal effect of puerarin; Many, easy to deteriorate; alcohol extraction method has a high yield, but the extraction process is complicated and inconvenient to operate, and the obtained puerarin has chemical solvents and heavy metal residues, which seriously affects the medicinal value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Prepare 1 kg of kudzu root, which is pulverized into 2mm crushed matter or particles by a pulverizer after drying, and sealed in an extraction tank;

[0017] (2) The pressure is set by the automatic control system as 30Mpa and the temperature is 40°C, and 4kg of carbon dioxide fluid in a supercritical state is introduced to carry out mixed extraction, so that the effective substances such as puerarin in the raw pueraria pueraria crumbs or granules are fully Dissolved in carbon dioxide fluid;

[0018] (3) adjust the pressure of the primary separation tank to be 12Mpa and the temperature to be 35°C, and the pressure of the secondary separation tank to be 6Mpa and the temperature to be 50°C;

[0019] (4) Pass the carbon dioxide fluid containing effective substances such as puerarin into the separation tank after the mixed extraction, set the carbon dioxide fluid flow rate as 25kg / h, extract for 3.5 hours, and obtain 199.3g of puerarin from the first-level separation ta...

Embodiment 2

[0021] (1) Prepare 1 kg of kudzu root, which is pulverized into 0.5mm crushed matter or particles by a pulverizer after drying, and sealed in an extraction tank;

[0022] (2) The automatic control system sets the pressure as 20Mpa and the temperature as the conditions of 50°C, and 4 kg of carbon dioxide fluid in a supercritical state is introduced for mixed extraction, so that the effective substances such as puerarin in the raw pueraria pueraria crumbs or granules are fully Dissolved in carbon dioxide fluid;

[0023] (3) adjust the pressure of the primary separation tank to be 9Mpa and the temperature to be 45°C, and the pressure of the secondary separation tank to be 5Mpa and the temperature to be 50°C;

[0024] (4) Pass the carbon dioxide fluid containing effective substances such as puerarin into the separation tank after the mixed extraction, set the carbon dioxide fluid flow rate as 10kg / h, extract for 3 hours, and obtain 235.2g of puerarin from the first-level separatio...

Embodiment 3

[0026] (1) Prepare 1 kg of kudzu root, which is pulverized into 0.5mm crushed matter or particles by a pulverizer after drying, and sealed in an extraction tank;

[0027] (2) The pressure set by the automatic control system is 18Mpa, the temperature is the condition of 55°C, and 7kg of carbon dioxide fluid in a supercritical state is introduced for mixed extraction, so that the effective substances such as puerarin in the raw pueraria pueraria crumbs or granules are fully Dissolved in carbon dioxide fluid;

[0028] (3) adjust the pressure of the primary separation tank to be 8Mpa and the temperature to be 50°C, and the pressure of the secondary separation tank to be 4Mpa and the temperature to be 55°C;

[0029] (4) Pass the carbon dioxide fluid containing effective substances such as puerarin into the separation tank after the mixed extraction, set the carbon dioxide fluid flow rate as 30kg / h, extract for 5 hours, and obtain 127.5g of puerarin from the first-level separation t...

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Abstract

The invention relates to a field of puerarin, and relates to a method for extracting puerarin. Specifically, an extraction and separation method is provided, wherein a carbon dioxide fluid under a supercritical state is adopted as an extracting agent, and an effective substance puerarin is extracted from pueraria lobata. The method is characterized in that: a raw material pueraria lobata is subjected to a drying treatment, and is crushed, wherein useful parts of the raw material pueraria lobata is crushed to pieces or particles with diameters of 0.5-2mm; supercritical carbon dioxide extraction is carried out; and primary and secondary reduced-pressure separations are carried out upon the carbon dioxide rich in the target extract substance. An obtained effective substance is puerarin with purity higher than 99%. According to the invention, separation and extraction are integrated, high-temperature heating is not needed, the entire process is controlled by using an automatic device, operation is convenient, process flow is greatly simplified, energy consumption and labor cost are saved, extraction and separation process is carried out in a full closed cycle, no environment pollution is caused, and the production is safe and environment-friendndly.

Description

technical field [0001] The invention relates to the field of puerarin and relates to a method for extracting puerarin. To be exact, it is an extraction and separation technology that uses carbon dioxide fluid in a supercritical state as an extraction agent to extract its effective substance, puerarin, from kudzu root. Background technique [0002] Pueraria lobata, which is a leguminous plant, contains about 12% flavonoids, including more than 10 kinds of daidzein, daidzein, puerarin, etc.; it also contains carrotin, amino acids, coumarins, etc. Used as medicine. Its quality varies with different planting places, and the quality of kudzu root cultivated or wild in Sui County, Suizhou City, Hubei Province is the best. [0003] Pueraria lobata contains nutrients such as puerarin, daidzein, and peanut, as well as protein, amino acid, sugar, and minerals such as iron, calcium, copper, and selenium that are necessary for the human body. It is a valuable tonic suitable for all ag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
CPCY02P20/54
Inventor 郭建军沈献礼冷培斌梁红梅朱珍黄俊张佳陈明
Owner 湖北万松堂大健康医药集团有限公司
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