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Application of statin medicines in preparing medicines used for treating chronic subdural hematoma

A technology of drugs and statins, which is applied in the field of statins, can solve the problems of statins not found, and achieve high safety and reliable effects

Inactive Publication Date: 2013-07-17
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the past 10 years, many researchers have confirmed that in addition to the function of regulating fat metabolism, statins also have the application of promoting the formation of neurovascular units and nerve repair. Reports for the treatment of CSDH

Method used

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  • Application of statin medicines in preparing medicines used for treating chronic subdural hematoma
  • Application of statin medicines in preparing medicines used for treating chronic subdural hematoma
  • Application of statin medicines in preparing medicines used for treating chronic subdural hematoma

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] Typical case 1: male, 70 years old, walking unsteadily and dizzy for 1 month due to minor head trauma half a year later, a CT scan in a hospital in Sichuan found bilateral subdural effusions. One month after the drilling and drainage operation, unsteady walking and dizziness occurred again. Confirmed by CT review (see figure 1 ) Hematoma recurrence (A, C). After receiving atorvastatin treatment (40mg / night, after a week, change to 20mg / night, long-term oral administration), the symptoms were significantly relieved after 2 weeks, and the hematoma was significantly reduced after a re-examination of CT after 1 month. Imaging at 3 months shows that the hematoma has almost disappeared (B, D).

example 2

[0027] Typical case 2: A 75-year-old male was admitted to the hospital due to a head injury and was temporarily unconscious for 2 hours. CT scan showed a cerebral hematoma and laceration of less than 10ml in the right frontal lobe. To conservative treatment, 1 month later improved and discharged. Six months after being discharged from the hospital, she found walking unsteady and dizzy. Repeat CT scan (see figure 2 ) left subdural hematoma (A). After receiving atorvastatin treatment (medication method: 20mg / night, lasting for 3 months), the symptoms were relieved after 2 weeks, and the hematoma was significantly reduced after 3 months of re-examination. Imaging after 1 year shows that the hematoma has almost disappeared (B).

Embodiment 3

[0029] Typical case 3: Male, 83 years old, was admitted to the hospital due to dizziness and unsteady walking for half a month due to a slight head injury. CT scan showed (see image 3 ) left subdural hematoma (A). After receiving atorvastatin treatment (medication method is the same as case 1), the symptoms were relieved after 2 weeks, and the hematoma almost disappeared after 3 months of re-examination (B).

[0030] The basic information of the other 18 patients whose hematoma has been reduced by oral administration of statin is shown in the table below* (the method of administration is the same as that of case 1):

[0031]

[0032] *Hematoma is calculated using the formula: length×width×layer thickness / 2; bilateral cases are calculated separately and added up.

[0033] ** Recurrence after surgery

[0034] ★Indicates that the statin used is simvastatin.

[0035] It has been clinically proven that statins such as lovastatin, mevastatin, and pravastatin can also promote ...

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Abstract

The invention discloses an application of statin medicines in preparing medicines used for treating chronic subdural hematoma (CSDH). The application provided by the invention has the advantages that: 1, the safety is high; the medicine does not cause severe complications; CSDH reoccurrence is prevented for a long time after applciation; and an effect is reliable; 2, medication is convenient and is easy to be accepted by patients, wherein the medicine needs to be taken only once a day, and an amount is appropriate, such that patient daily lives are not affected; 3, the medicine is economical, wherein the medicine can be orally taken at home, such that hospitalization costs, surgical treatment costs, and care worker costs before and after surgery are avoided; and 4, defects such as anesthesia risk, pain risk, surgical bleeding, brain physiological cycle disruption, brain function damage, postoperative infection and recurrence, and the like of a traditional borehole drainage operation used for treating CSDH are avoided.

Description

technical field [0001] The present invention relates to the use of a medicine, in particular to the use of a statin medicine. Background technique [0002] The existing technology is divided into two parts, one is the existing treatment technology for Chronic Subdural Hematoma (CSDH); the other is the new use of statins. [0003] Chronic subdural hematoma (Chronic Subdural Hematoma, CSDH) is one of the common diseases in neurosurgery, with an incidence rate of about 1-13.1 per 100,000 people per year (1，2) . Most patients are elderly. As the proportion of my country's aging structure increases year by year, there are more and more elderly patients and those who receive stents for heart or cerebrovascular diseases or receive heart bypass and cerebrovascular bypass. The use of anticoagulants is very common. Refractory CSDH or repeated recurrence CSDH is gradually increasing and is becoming another difficult problem for neurosurgeons. Although there are many studies on CSDH,...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/366A61K31/40A61P25/00A61P9/10
Inventor 张建宁江荣才
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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