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Novel use of pentapeptide and metabolite thereof in preparation of anti-dementia product

A technology of metabolites and uses, applied in the field of reagent technology, can solve the problems such as reports on anti-dementia products of small peptides and their metabolites that have not yet been found, and achieve the advantages of significant brain permeability, easy passage, and reduce the burden of monitoring.

Active Publication Date: 2013-07-10
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0056] However, through literature search, etc., so far, no report on the use of this small peptide and its metabolites for the preparation of anti-dementia products, etc. has been found.

Method used

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Examples

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Effect test

preparation example Construction

[0168] As for the preparation methods of small peptides used to prepare anti-dementia products, they are all mature methods, which have been published in various journals and patent documents, and will not be repeated in the present invention.

[0169] In the present invention, the specific implementation manners described above and the examples described below are for better illustrating the present invention, and are not used to limit the scope of the invention.

Embodiment 1

[0172] Embodiment 1, the preparation of small peptide

[0173] ① The amino acid sequence of the pentapeptide MLIF is shown in SEQ ID NO: 1: Met-Gln-Cys-Asn-Ser.

[0174] ② The amino acid sequence of the tetrapeptide QS is shown in SEQ ID NO: 2: Gln-Cys-Asn-Ser.

[0175] ③ The amino acid sequence of the tetrapeptide MN is shown in SEQ ID NO: 3: Met-Gln-Cys-Asn.

[0176] ④ The amino acid sequence of the tripeptide CS is shown in SEQ ID NO: 4: Cys-Asn-Ser.

[0177] ⑤ The amino acid sequence of the tripeptide MC is shown in SEQ ID NO: 5: Met-Gln-Cys.

[0178] ⑥ The amino acid sequence of the dipeptide MQ is shown in SEQ ID NO: 6: Met-Gln

[0179] ⑦ The amino acid sequence of the dipeptide NS is shown in SEQ ID NO: 7: Asn-Ser.

[0180] The above small peptides were synthesized by Guangdong Bajiayi Pharmaceutical Co., Ltd., with a purity of more than 98%.

Embodiment 2

[0181] Embodiment 2, to the protective effect of the vascular dementia rat model that middle cerebral artery embolization method makes

[0182] 2.1 Establishment of vascular dementia rat model produced by middle cerebral artery embolization method Rats were treated with 10% chloral hydrate 350mg·kg -1 Intraperitoneal injection of anesthesia, median neck incision, separation and ligation of the proximal end of the right common carotid artery, external carotid artery and its branch arteries. The right internal carotid artery was separated, the pterygognathic artery was separated downward along the internal carotid artery, and the root of the branch was ligated. An incision was made at the bifurcation of the common carotid artery, and a nylon thread was inserted to a depth of 17-20mm. The thread was tied into the internal carotid artery, and then into the cranium to the anterior cerebral artery, blocking all sources of blood flow in the middle cerebral artery. After 2 hours of i...

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Abstract

The invention relates to the technical field of biological medicines and in particular relates to a novel use of pentapeptide and metabolite thereof in preparation of an anti-dementia product. Amino acid sequences of the small peptide are as shown in Seq No.1, No.2, No.3, No.4, No.5 and No.6. According to the pharmacological experiment of the alzheimer disease and vascular dementia animal model, the small peptide and the metabolite thereof can be used for remarkably improving the cognitive function of the dementia, so that the small peptide and the metabolite thereof have the effects of preventing the alzheimer disease and vascular dementia, and therefore, the pentapeptide and metabolite thereof can be used for preparing the medicine for preventing senile dementia including the alzheimer disease and vascular dementia.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food, reagents, etc., in particular to a new use of a small peptide and its metabolites in biomedical technology, and more specifically to a pentapeptide that inhibits the movement of monocytes Factors and some of their metabolites are used in the preparation of anti-dementia products, and more specifically, a new application involving 6 small peptides in the preparation of anti-dementia products, especially senile dementia, including Alzheimer's disease and vascular dementia products in the application. Background technique [0002] 1. Overview of research on vascular dementia [0003] Dementia (Dementia) is an acquired and persistent mental retardation syndrome caused by brain dysfunction. Comprehensive impairment of higher neurological functions including varying degrees of memory, language, visuospatial function, personality abnormalities, and cognitive decline. Vascular dementia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K38/07A61K38/06A61K38/05A23L1/29A61P25/28A23L33/00
Inventor 李铁军芮耀诚章越凡杨鹏远张恩德黄景华王习著
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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