Efficient painless drug for treating local tumor ablation
A technology for the treatment of drugs and tumors, used in anti-tumor drugs, drug combinations, drug delivery, etc., can solve problems such as poor overall efficacy, achieve complete tumor inactivation, improve compliance, and reduce pain response effects.
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[0012] 1. Preparation of mixed injection medicine
[0013] Under sterile conditions, accurately absorb absolute ethanol and lauromacrogol, and mix them thoroughly at a volume ratio of 19 / 1 (V / V) to obtain a mixed injection (that is, 95% ethanol by volume + 5% polyol by volume). cinnamyl alcohol mixture), and stored at 4°C for later use.
[0015] Take 32 Kunming mice, weighing 18-22 g, half male and half male, and randomly divide them into 4 groups: normal saline control group (A), 2% lidocaine control group (B), lauromacrogol injection group ( C), 95% ethanol + 5% lauromacrogol mixture group (D). 10 μl of the above-mentioned corresponding drugs were subcutaneously injected into the foot pad of the left hind limb of the mice with a micro-injector, and 10 μl of 1% formalin was injected again along the needle track 5 minutes later, the pain response of the mice was observed for 2 minutes, and the score was calculated. 3 points for licking, bitin...
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