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Carbazole alkaloids of clausena lansium and preparation method thereof and medical composition and use thereof

The technology of a carbazole alkaloid and a composition is applied in the application field of preparing a drug for treating neurodegenerative diseases, and can solve the problems of unclear mechanism of action, complex traditional Chinese medicine ingredients, unclear effective ingredients and the like

Active Publication Date: 2013-06-26
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of traditional Chinese medicine is complex, the active ingredients are not clear, the curative effect is unstable, and the mechanism of action is not clear, which seriously affects the clinical use and the entry of Chinese medicine into the international mainstream market. Drugs for the treatment of degenerative diseases are an urgent task for medical researchers for a long time to come

Method used

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  • Carbazole alkaloids of clausena lansium and preparation method thereof and medical composition and use thereof
  • Carbazole alkaloids of clausena lansium and preparation method thereof and medical composition and use thereof
  • Carbazole alkaloids of clausena lansium and preparation method thereof and medical composition and use thereof

Examples

Experimental program
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Effect test

experiment example 1

[0061] Experimental example 1: Effect of the compound of the present invention on the survival state of rat cerebral cortex neurons and its protective effect in the model of neuron apoptosis induced by sodium nitroprusside

[0062] In the study of the effect of the compound on the survival state of neurons, the primary cultured rat cortical neurons (DIV-9) were divided into a control group and an administration group (10 μM), n=6; In the study of the protective effect of the apoptosis model, the primary cultured rat cortical neurons (DIV-7) were divided into the control group, the sodium nitroprusside (350 μM) model group, and the sodium nitroprusside (350 μM) + edaravone ( 100 μM) administration group, sodium nitroprusside (350 μM)+compound (10 μM) administration group, n=6. After administration, the cells were placed in a cell incubator to continue culturing for 24 hours, and the cell viability was measured by the MTT method (570 nm). Taking the absorbance of the control gr...

experiment example 2

[0071] Experimental Example 2: The protective effect of the compound on glutamate-induced apoptosis of rat cortical neurons

[0072] The primary cultured rat cortical neurons (DIV-9) were divided into control group, glutamate (20mM) modeling group, glutamate (20mM)+edaravone (100μM) administration group, glutamate (20 mM)+compound (10 μM) administration group, n=6, after continuing to culture in the cell incubator for 24 hours, the cell viability was measured by MTT method. Taking the absorbance of the control group as the standard, the ratio of the absorbance of each group to the control group was calculated.

[0073] Table 3 Effects of Compounds on Glutamate-Induced Apoptosis of Rat Cortical Neurons

[0074]

[0075] Note: The survival rate is expressed as Mean±S.E.M

[0076] ###P*** P** P<0.01 vs glutamate model group.

[0077] The experimental results show that after modeling with glutamic acid, the survival rate of neurons is significantly reduced, while the surviva...

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Abstract

The invention discloses carbazole alkaloids of clausena lansium and a preparation method thereof and a medical composition and use thereof. In particular, the invention discloses ten new carbazole alkaloids (1-10) from Clausena lansium (lour.)skeels, the preparation method of the carbazole alkaloids through phytochemistry, the medical composition comprising the carbazole alkaloids and application thereof in preparing medicines for treating neurodegenerative diseases, in particular stroke or stupid.

Description

technical field [0001] The invention discloses a preparation method of ten new carbazole alkaloids (1-10) as active ingredients in Clausena lansium (lour.) skeels, a pharmaceutical composition containing new carbazole alkaloids, and their use in preparing and treating neurodegeneration application in disease medicine. Background technique [0002] Clausena lansium (lour.) skeels is a Clausena plant of Rutaceae Rutaceae. It is mainly produced in southern my country. It is widely planted in Fujian, Guangdong, Taiwan, Guangxi, Yunnan and other places. Its roots, branches, leaves, fruits and The seeds are used as medicine. The nature and flavor of the branches and leaves of the yellow bark belong to Xinliang (Luchuan Materia Medica). [0003] As my country's aging society accelerates, the number of elderly people continues to increase. According to statistics, by 2020, my country's aging level will reach 17.17%, and the number of patients with various geriatric diseases is als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/18C07D491/052C07D491/048C07D209/94C07D209/88A61K31/407A61K31/403A61P25/00A61P9/10A61P25/28
Inventor 张东明陈乃宏柳航宁娜
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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