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Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation

A phenophotosensitizer and nanomedicine technology, which is applied in the field of hydrophobic chlorin photosensitizer nanomedicine preparation and preparation, can solve problems such as rising cost and achieve the effects of simple structure, increased accumulation and low cost

Inactive Publication Date: 2014-11-26
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are four hydroxyl groups on the molecule of temoporfin, which has good water solubility, but the hydroxyl groups need to be protected and deprotected during the synthesis process, which will cause an increase in the cost of drug synthesis

Method used

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  • Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation
  • Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation
  • Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation and application of a nano-pharmaceutical preparation of a photosensitizer based on human serum albumin:

[0041] Human serum albumin was dissolved in water to form a 10 mg / ml aqueous solution of human serum albumin.

[0042] The photosensitizer m-tetraphenylchlorin was dissolved in tetrahydrofuran to form a 1 mg / ml photosensitizer solution.

[0043] During stirring, 10 ml of photosensitizer solution (1 mg / ml) was added dropwise to 50 ml of human serum albumin solution (10 mg / ml) to obtain a mixed solution.

[0044] Centrifuge (13,000 rpm) to mix the solution, remove the precipitate, and collect the supernatant.

[0045] The obtained supernatant was dialyzed to obtain a photosensitizer nano drug solution of human serum albumin, which was sterilized by filtration with a 0.22 micron filter membrane. Concentrate to obtain the nano drug solution of human serum albumin-photosensitizer.

[0046] Add the photosensitizer nano-drug solution based on human serum alb...

Embodiment 2

[0048] Preparation and application of a nano-pharmaceutical preparation of a photosensitizer based on human serum albumin:

[0049] Human serum albumin was dissolved in water to form a 5 mg / ml aqueous solution of human serum albumin.

[0050] The photosensitizer m-tetraphenylchlorin was dissolved in tetrahydrofuran to form a 1 mg / ml photosensitizer solution.

[0051] During stirring, 12 ml of photosensitizer solution (1 mg / ml) was added dropwise to 50 ml of human serum albumin solution (5 mg / ml) to obtain a mixed solution.

[0052] Centrifuge (14800 rpm) to mix the solution, remove the precipitate, and collect the supernatant.

[0053] The obtained supernatant was dialyzed to obtain a photosensitizer nano drug solution of human serum albumin, which was sterilized by filtration with a 0.22 micron filter membrane. Concentrate to obtain the nano drug solution of human serum albumin-photosensitizer.

[0054] Add the photosensitizer nano-drug solution based on human serum albumi...

Embodiment 3

[0056] Preparation of a nano-pharmaceutical preparation of a photosensitizer based on human serum albumin:

[0057] Human serum albumin was dissolved in water to form a 5 mg / ml aqueous solution of human serum albumin.

[0058] The photosensitizer m-tetraphenylchlorin was dissolved in ethanol to form a 0.2 mg / ml photosensitizer solution.

[0059] During stirring, 15 ml of photosensitizer solution (0.2 mg / ml) was added dropwise to 50 ml of human serum albumin solution (5 mg / ml) to obtain a mixed solution.

[0060] Centrifuge (14800 rpm) to mix the solution, remove the precipitate, and collect the supernatant.

[0061] The obtained supernatant was dialyzed to obtain a photosensitizer nano drug solution of human serum albumin, which was sterilized by filtration with a 0.22 micron filter membrane. Concentrate to obtain the nano drug solution of human serum albumin-photosensitizer.

[0062] The photosensitizer nano drug solution based on human serum albumin was injected into the ...

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Abstract

The invention discloses a hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation. The preparation is only composed of albumin and hydrophobic dihydroporphin photosensitizer and is free of other cross-linking agents or auxiliary materials. The used hydrophobic dihydroporphin photosensitizer is simple in structure, free of hydroxyl, alkoxyl, amino group and the like, capable of improving water-soluble functional groups of the dihydroporphin photosensitizer and easy to synthesize. The invention further discloses a preparation method and application of the nanometer medicine pharmaceutic preparation.

Description

technical field [0001] The invention relates to a nano-medicine preparation, in particular to an albumin-based hydrophobic chlorphine photosensitizer nano-medicine preparation, a preparation method and an application thereof. Background technique [0002] Serum albumin is widely distributed in the blood. Serum albumin is a protein with the most content in plasma, the smallest molecule, high solubility and many functions. Due to its degradability, serum albumin is considered as a potential and safe drug carrier. Since albumin contains amino, carboxyl, and sulfhydryl functional groups, previous studies have obtained albumin nanoparticles by introducing cross-linking agents, and further loading chemotherapeutic drugs and hydrophilic chlorin derivatives on albumin nanoparticles Molecules, expected to improve drug distribution in lesion sites (US2006 / 0234960A1; US2011 / 0142948A1; US2011 / 0275686A1; CN101569609A; CN1736489A). [0003] In 1976, the clinical application of a hemato...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/42A61K9/19A61K9/14A61P35/00
Inventor 张晓宏安菲菲
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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