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Industrial production method of high-purity N-lauroyl-L-alanine surfactant

A technology for surfactants and production methods, applied in chemical instruments and methods, separation/purification of carboxylic acid amides, organic chemistry, etc., can solve the problems of difficulty in realizing industrialized large-scale production, great influence on product quality, and low product purity, etc. The method is simple and practical, the appearance and color are good, and the content is high.

Inactive Publication Date: 2013-06-05
SUZHOU WEIMEI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The resulting product has low purity and a lot of impurities, which have a great impact on the quality of the product. Special methods, such as column purification, can be purified to a purity of more than 98%. The operation is troublesome and the cost is high, so it is difficult to realize industrialized large-scale production

Method used

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  • Industrial production method of high-purity N-lauroyl-L-alanine surfactant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] At room temperature, in a 1000ml four-neck flask, dissolve 89g (1mol) L-alanine in 200mL water, add 40g (1mol) NaOH, then add 200mL acetone and stir well; control the temperature at 24-26°C, slowly and uniformly Add 198.6g (0.9mol) of lauroyl chloride dropwise, drop it for about 1 hour, then add about 72mL of 50% sodium hydroxide aqueous solution dropwise, carefully control the pH value of the reaction solution at about 9, after the dropwise addition, in 24-26 ℃ and then continue to keep the pH between about 9 and react for 2 hours until the pH remains unchanged. A white paste reactant is obtained. Stop the reaction and acidify it with 0.6mol / L hydrochloric acid to pH 3-4. Solids gradually precipitate out and place in an ice bath. After 2 hours, it was filtered, and the obtained solid was stirred and washed twice with water, and dried to obtain 234 g of crude N-lauroyl-L-alanine.

[0028] Get crude product 100g, be dissolved in the mixed solvent of 400mL, described mixe...

Embodiment 2

[0030] At room temperature, in a 1000mL four-neck flask, dissolve 89g (1mol) L-alanine in 200mL water, add 56g (1mol) KOH, then add 200mL acetone and stir well; control the temperature at 24-26°C, slowly and uniformly Add 198.6g (0.9mol) of lauroyl chloride dropwise, drop it for about 1 hour, then add about 100mL of 50% KOH aqueous solution dropwise, carefully control the pH value of the reaction solution at about 9, and continue at 24-26°C after the dropwise addition Keep the pH at about 9 and react for 2 hours until the pH remains unchanged. A white paste reactant is obtained. Stop the reaction and acidify it to pH 3-4 with 0.6mol / L hydrochloric acid. Solids gradually precipitate out and stand in an ice bath for 2 hours. , filtered, the obtained solid was stirred and washed twice with water, and dried to obtain 231.1 g of crude N-lauroyl-L-alanine.

[0031] Get crude product 100g, be dissolved in 400mL mixed solvent, described mixed solvent is made up of 100mL acetone, 100mL...

Embodiment 3

[0033] At room temperature, in a 1000mL four-neck flask, dissolve 89g (1mol) L-alanine in 200mL water, add 53g (0.5mol) Na2CO3, then add 200mL acetone and stir well; control the temperature at 24-26°C, slowly Add 198.6g (0.9mol) lauroyl chloride dropwise at a constant speed, and drop it in about 1 hour, then add about 95mL of 50% sodium carbonate aqueous solution dropwise, carefully control the pH value of the reaction solution at about 9, after the dropwise addition, at 24-26°C Continue to keep the pH between about 9 and react for 2 hours until the pH remains unchanged, and a white paste reactant is obtained. Stop the reaction and acidify it to pH 3-4 with 0.6mol / L hydrochloric acid. hours, filtered, and the obtained solid was stirred and washed twice with water, and dried to obtain 226 g of crude N-lauroyl-L-alanine.

[0034] Get crude product 100g, be dissolved in 400mL mixed solvent, described mixed solvent is made up of 100mL acetone, 100mL ethanol, 200mL water, heat and ...

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Abstract

The invention discloses an industrial production method of a high-purity N-lauroyl-L-alanine surfactant, which comprises the following steps: A, dissolving a certain amount of alanine and a metal inorganic base in a certain amount of mixed solvents of distilled water and organic solvents to prepare an alanine salt; B, slowly and dropwisely adding metered lauroyl chloride into the reaction solution at a certain temperature, dropwisely adding the metal inorganic base solution with a certain concentration to maintain the pH value of the reaction system to be a specified value, after the dropwise addition, continuing to stirring for a specified time to generate an N-lauroyl-L-alanine salt; C, after the reaction is stopped, acidifying the product with dilute hydrochloric acid to obtain a pH of 3-4, precipitating solids, performing suction filtration, stirring and washing the obtained solid with water twice, performing recrystallization of the crude product with a solvent, performing heating reflux, cooling, filtration, and drying to obtain white powdery N-lauroyl-L-alanine with high purity of more than 98%. The method of the invention is simple, practical, low in cost, high in production efficiency, and suitable for industrial production.

Description

technical field [0001] The present invention relates to a kind of production method of high-purity N-lauroyl-L-alanine surfactant, especially a kind of high-purity N-lauroyl-L-alanine which is simple and practical, low in cost and high in production yield. The invention relates to an industrial production method of an alanine surfactant, which belongs to the technical field of industrial preparation of amino acid surfactants. Background technique [0002] Surfactants refer to those substances that have strong surfactants and can significantly reduce the surface tension of liquids. A wide range of surfactants (cationic, anionic, nonionic and amphoteric) provide a variety of functions for specific applications, including wetting or anti-sticking, emulsifying or breaking, foaming or defoaming and solubilizing, dispersing, washing, Anti-corrosion, anti-static, etc., are a class of flexible and versatile fine chemical products. [0003] Although ordinary surfactants are widely ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/47C07C231/02C07C231/12C07C231/24
Inventor 张健
Owner SUZHOU WEIMEI BIOLOGICAL TECH
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