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Compound medicament for treating chronic liver disease and preparation method thereof

A technology for chronic liver disease and medicine, applied in the field of compound medicine and preparation for treating chronic liver disease, can solve the problems of large toxic and side effects, unsatisfactory effect, limited clinical application, etc., and achieve the effect of exact curative effect

Active Publication Date: 2013-06-05
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although existing drugs have been widely used clinically, their effects are still not ideal, and their toxic and side effects are generally large, so their clinical application is greatly limited.

Method used

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  • Compound medicament for treating chronic liver disease and preparation method thereof
  • Compound medicament for treating chronic liver disease and preparation method thereof
  • Compound medicament for treating chronic liver disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 (based on the preparation of 1000ml, oral preparations are prepared)

[0027] a. Mix and grind 20 parts of Artemisia caprifolia, 70 parts of Artemisia annua, 50 parts of chicory, 5 parts of rose, 5 parts of rhubarb, and 30 parts of licorice into 10 meshes, and extract once with 4 times the amount of water , the temperature is 30°C, and the extraction time is 4 hours to obtain a water extract;

[0028] b. Take the water extract, filter and separate the medicinal residue and the medicinal liquid, concentrate the medicinal liquid under reduced pressure, precipitate with ethanol, the concentration of alcohol precipitation is 40%, filter, and the filtrate will be concentrated under reduced pressure into an extract with a relative density of 1.10-1.40 , filtered to obtain the water extract extract;

[0029] c. Add purified water to the water extract extract, add 5 parts of stevioside and 5 parts of sorbic acid, filter with plate and frame, pack in 10ml, 20ml, 10...

Embodiment 2

[0030] Embodiment 2 (based on the preparation of 1000ml, oral preparations are prepared)

[0031] a. Mix and grind 20 parts of Artemisia caprifolia, 70 parts of Artemisia argyi, 50 parts of Chicory, 5 parts of rose, 5 parts of rhubarb, and 30 parts of licorice into 10 meshes, and extract with 10% ethanol 4 1 time, the temperature is 30°C, the extraction time is 4 hours, and the ethanol extract is obtained;

[0032] b. Filter the alcohol extract to separate the medicinal residue and the medicinal liquid, combine the medicinal liquid, concentrate under reduced pressure to form an extract with a relative density of 1.10-1.40, and filter to obtain the alcohol extract;

[0033] c. Add pure water to the alcohol extract of step b, add 5 parts of stevioside, 5 parts of sorbic acid, plate and frame filter, pack in 10ml, 20ml, 100ml or 200ml per bottle or tube, and sterilize according to the conventional method Made into oral liquid preparations.

Embodiment 3

[0034] Embodiment 3 (based on preparing 1000ml, prepare syrup)

[0035] a. Mix and grind 50 parts of Artemisia caprifolia, 30 parts of Artemisia annua, 5 parts of chicory, 50 parts of rose, 30 parts of rhubarb, and 10 parts of licorice to 50 mesh, and use 8 times the concentration of 10% The ethanol extraction was performed twice at a temperature of 50° C., and each extraction time was 2 hours to obtain an ethanol extract;

[0036] b. The ethanol extract is filtered to separate the medicinal residue and the medicinal liquid, the medicinal liquid is combined, concentrated under reduced pressure into an extract with a relative density of 1.10-1.40, and filtered to obtain an alcohol extract extract;

[0037] c. Add pure water to the extract of the alcohol extract in step b, add 40 parts of sucrose to dissolve evenly, filter, pack in 10ml, 20ml, 100ml, 200ml or 300ml per bottle or tube, sterilize, and make syrup according to the conventional method agent.

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Abstract

The invention relates to a compound medicament for treating a chronic liver disease and a preparation method thereof. The compound medicament is prepared from artemisia capillaries, artemisia rupestris, cichorium glandulosum boiss et huet, rose, rhubarb and licorice which are used as raw materials and medicinal accessories and prepared into an oral preparation, syrup granules, hard capsules and tablets by adopting a method of solvent extraction, impurity removal, concentration and drying. The active ingredients in the compound medicament are dissolved by adopting a reasonable extraction method according to the Uyghur medicinal theory, the characteristics of national medicine and the long-term folk clinical practice of the Uyghur nationality, so that the medicinal effects are enhanced, and the bioavailability is improved. Animal experiments prove that the compound medicament has a protective effect on liver injury. Pharmacodynamic experiments show that the extract obtained by the method can inordinately reduce the alanine transaminase (ALT) and aspartate transferase (AST) levels in mouse serum of a liver injury model, the pathological symptoms in each medication administration team are relieved, and the liver injury is protected. Acute toxicity experiments show that the maximum dosage of the extract obtained by the method is equivalent to 337 folds of clinical human proposed dosage according to mouse intragastric single-time administration toxicity test, and the extract is nontoxic and safe.

Description

technical field [0001] The invention relates to a compound medicine for treating chronic liver disease and a preparation method thereof, belonging to the technical field of Uighur medicine and ethnic medicine. Background technique [0002] Chronic liver disease is caused by inflammation of the liver and liver cell necrosis and persistent acute hepatitis (B or C). If the course of the disease exceeds half a year, some hepatitis has an insidious onset. When the disease is discovered clinically, it has become chronic hepatitis. With the continuous development of chronic hepatitis, the degree of liver damage will often be increased, which will cause liver cell inflammation, necrosis, and the pathological process of secondary fibrosis. Liver fibrosis is the development of liver cirrhosis and even primary liver cancer. an intermediate link. As a large country with liver disease infection, there are about 120 million chronically infected people in China. Among them, chronic hepat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P1/16
Inventor 阿吉艾克拜尔·艾萨
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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