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Application of valeriana jatamansi jones or extracts thereof in preparation of medicine for lowering fat and protecting liver

A lipid-lowering, liver-protecting, and spider-flavor technology is applied in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve problems such as differences in drug effects, and the lack of spider-flavor's blood-lipid-lowering and liver-protecting effects.

Inactive Publication Date: 2011-11-16
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, although valerian and spider incense belong to different plants of the same genus, they have different medicinal effects. At present, there are no relevant reports on the blood lipid-lowering and liver-protecting effects of spider incense at home and abroad.

Method used

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  • Application of valeriana jatamansi jones or extracts thereof in preparation of medicine for lowering fat and protecting liver
  • Application of valeriana jatamansi jones or extracts thereof in preparation of medicine for lowering fat and protecting liver
  • Application of valeriana jatamansi jones or extracts thereof in preparation of medicine for lowering fat and protecting liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 The preparation of the spider incense extract of the present invention

[0018] Weigh 200g of the original medicinal material fine powder of spider incense, use 80% ethanol, 10 times the amount of ethanol, 40KHz, extract 90min ultrasonic extraction twice, filter, combine the two filtrates, 40 ° C rotary steam concentration to liquid extract, and 0.5% CMC -Na solution is fixed to 660mL, which is equivalent to containing 0.3g of crude drug per milliliter.

Embodiment 2

[0019] Example 2 The preparation of the spider incense extract of the present invention

[0020] Weigh 200g of the original medicinal material fine powder of spider incense, use 95% ethanol, 5 times the amount of ethanol, 59KHz, extract 30min ultrasonic extraction twice, filter, combine the two filtrates, 40 ° C rotary evaporation concentrated to liquid extract, and 0.5% CMC -Na solution is fixed to 660mL, which is equivalent to containing 0.3g of crude drug per milliliter.

Embodiment 3

[0021] Example 3 The preparation of the spider incense extract of the present invention

[0022] Weigh 200g of the original medicinal material fine powder of spider incense, use 60% ethanol, 15 times the amount of ethanol, 80KHz, extract 60min, ultrasonically extract twice, filter, combine the two filtrates, 40°C rotary steaming and concentrating to liquid extract, and 0.5% CMC -Na solution is fixed to 660mL, which is equivalent to containing 0.3g of crude drug per milliliter.

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PUM

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Abstract

The invention provides application of valeriana jatamansi jones or extracts thereof in the preparation of a medicine for lowering the fat and protecting the liver. The invention also provides a pharmaceutical composition for lowering the fat and protecting the liver. Animal experiments prove that the valeriana jatamansi jones or the extracts thereof has / have the functions of reducing blood fat and serum AST (aspartate transaminase), ALT (alanine transaminase), and can be used for the treatment of hyperlipidemia with definite efficacy thereby providing a new choice the clinic.

Description

technical field [0001] The invention relates to a new application of spider incense or its extract, in particular to a new application in the preparation of liver-protecting and lipid-lowering drugs, which belongs to the field of medicines. Background technique [0002] Spider incense (Valeriana jatamansi Jones) is a plant of Valerianaceae (Valerianaceae) genus Valeriana (Valeriana Linn). "Collection", Stinky Medicine "Common Herbal Medicine Treatment Handbook", Vanilla Seed "Shaanxi Chinese Herbal Medicine", etc. Spider incense was once recorded in "Southern Yunnan Materia Medica" and "Compendium of Materia Medica", as well as in the 1977 and 2010 editions of "Chinese Pharmacopoeia (Part One)", saying that it is "warm in nature, pungent in taste, slightly bitter, and warm in heart, spleen, and stomach." Meridian, functions of regulating qi and relieving pain, eliminating food and relieving diarrhea, expelling wind and dampness, calming the nerves, and is used for abdominal...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61P3/06A61K125/00
Inventor 闫智勇陈朝勇李少华陈冲张天娥
Owner SOUTHWEST JIAOTONG UNIV
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