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Application of vitexin in preparing drug with cough and asthma relieving action

A technology for relieving cough and asthma, and vitexin, which is applied in the field of medicine and can solve problems such as unsatisfactory treatment effects

Inactive Publication Date: 2013-05-22
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic effects of these drugs are not very satisfactory, and it is very necessary to find more effective drugs for the treatment of chronic obstructive pulmonary disease

Method used

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  • Application of vitexin in preparing drug with cough and asthma relieving action
  • Application of vitexin in preparing drug with cough and asthma relieving action
  • Application of vitexin in preparing drug with cough and asthma relieving action

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Ammonia induced cough test

[0028] 40 Kunming mice were randomly divided into control group, vitexin high-dose group (12 mg / kg), vitexin medium-dose group (6 mg / kg), vitexin low-dose group (3 mg / kg), each group 10 only. The experiment started 1 h after intragastric administration. Take one mouse at a time, put it into a glass cover with a volume of 1 L, and put a piece of filter paper (2×2 cm 2 ), drop 0.3 ml of ammonia water onto the filter paper, and stimulate the mice in the glass cover for 30 s. Immediately observe and record the cough times and cough latency of the mice within 2 min after taking them out. open mouth. After 3 hours of gavage, repeat the experiment once, observe and record.

[0029] Table 1 Inhibitory effect of vitexin on cough induced by ammonia water in mice

[0030]

[0031] Note: *P<0.01 means significant or very significant difference.

[0032] The experimental results showed that the three dose groups of vitexin could signif...

Embodiment 2

[0033] Example 2 Inhalation test of acetylcholine chloride plus histamine phosphate

[0034] Take 40 guinea pigs of 200-250 g, half male and half female, put them in a 5000 mL volume airtight glass beaker, spray 1% acetylcholine chloride and 0.2% histamine phosphate equal volume mixture for 10 seconds with an ultrasonic nebulizer. The guinea pigs were taken out immediately, and the incubation period of wheezing induced by the guinea pigs was observed (from the beginning of spraying to the onset of asthma, extreme difficulty in breathing, and the time until convulsions and falls). Then the guinea pigs were randomly divided into control group, vitexin high-dose group (4mg / kg), vitexin medium-dose group (2mg / kg), vitexin low-dose group (1mg / kg), 10 in each group. Induce asthma 1h and 3h after administration respectively, and observe the incubation period of asthma induction. The latent period of asthma induction was calculated as 120 s for those who did not breathe for more than...

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Abstract

The invention relates to the technical field of traditional Chinese medicines, provides application of vitexin in preparing a drug with cough and asthma relieving action and in particular relates to the application in preventing and treating asthma, chronic obstructive pulmonary diseases (COPD), chronicbronchitis and cold and cough.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the application of vitexin in the preparation of drugs with antitussive and antiasthmatic effects, and more specifically to the application of vitexin in the preparation of prevention and treatment of asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and Application in cold and cough medicine. Background technique [0002] Vitex Vitex is a perennial plant of Verbenaceae Vitex negundo The fruit of L.var. cannabifolia (sieb. Et Zucc) Hand. Mazz with persistent calyx is also called Xiaojingshi. It is recorded in "Dictionary of Traditional Chinese Medicine" and "Compendium of Materia Medica" that "Vexaceae is bitter, warm, and non-toxic. , mainly removes cold and heat between bones, promotes stomach qi, relieves cough and lowers qi." It has the effects of eliminating phlegm and relieving cough, relieving asthma, regulating qi and relieving pain, and is often u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P11/06A61P11/14A61P11/00A61K45/00
Inventor 陈广通宋妍许伯慧杨雪黄金华汪冬庚
Owner NANTONG UNIVERSITY
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