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External preparation for treating rheumatism pain disease, as well as preparation method and application thereof

A technology for rheumatism arthralgia and external preparations, applied in the directions of medical preparations containing active ingredients, non-central analgesics, anti-inflammatory agents, etc., can solve the problem that the extraction process does not consider the properties of the active ingredients of traditional Chinese medicine and the stability of product quality Unable to guarantee, not meeting the requirements of modernization of traditional Chinese medicine, etc., to achieve the effects of perfect product quality control, saving medicinal materials, and easy absorption

Inactive Publication Date: 2013-05-15
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, existing bibliography reports the treatment method of rheumatism arthralgia, but all used in the prior art is generous of more than 10 herbal medicines, all are simple water extraction, brewing in wine, direct crushing and other traditional techniques, and there is no Any quality standard control, the extraction process does not consider the properties of the active ingredients in each traditional Chinese medicine, the stability of product quality cannot be guaranteed, it is very difficult to develop into medicines, and it does not meet the requirements of modernization of traditional Chinese medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Weigh 20g of Aconitum aconiti, 10g of ephedra, 30g of safflower, 50g of geranium, and 50g of Sperancus.

[0074] Aconitum aconitum was soaked in 70% ethanol for 24 hours, 12 times the amount of 70% ethanol was refluxed and extracted 3 times, each time for 2 hours, filtered, and the filtrate was combined; safflower was added with 15 times the amount of water, extracted twice, each time for 20 minutes, Filter and combine the filtrates; mix the Aconitum aconitum extract and the safflower extract and concentrate to a thick paste with a relative density of 1.30-1.40 (50°C). Mix ephedra and geranium evenly, add 10 times the amount of 50% ethanol, reflux extraction 3 times, each time for 1.5 hours, filter, combine the filtrate and concentrate to a thick paste with a relative density of 1.30~1.35 (50°C), and at 50°C, Under the condition of -0.08Mpa, it is dried under vacuum and reduced pressure to form a dry paste. Add 15 times the amount of 80% ethanol to Speranthema, extract...

Embodiment 2

[0076] Weigh 50g of Aconitum aconiti, 50g of Ephedra, 50g of Safflower, 30g of Geranium, and 30g of Sperancus.

[0077] Aconitum aconitum was soaked in 80% ethanol for 36 hours, 15 times the amount of 80% ethanol was refluxed and extracted twice, each time for 5 hours, filtered, and the filtrate was combined; safflower was added with 20 times the amount of water, extracted twice, each time for 40 minutes, Filter and combine the filtrates; mix the Aconitum aconitum extract and the safflower extract and concentrate to a thick paste with a relative density of 1.10-1.15 (50°C). Mix ephedra and geranium evenly, add 20 times the amount of 70% ethanol, extract twice, 2 hours each time, filter, combine the filtrate and concentrate to a thick paste with a relative density of 1.40~1.45 (50°C), and at 50°C, - Under the condition of 0.08Mpa, it is vacuum-dried under reduced pressure to form a dry paste. Add 10 times the amount of 30% ethanol to the Sperantoides, extract twice, 3 hours each...

Embodiment 3

[0079] Weigh 5g of Aconitum aconiti, 5g of ephedra, 10g of safflower, 10g of geranium, and 10g of Sperancus.

[0080] Aconitum aconitum was soaked in 95% ethanol for 36 hours, 20 times the amount of 95% ethanol was refluxed and extracted 4 times, each time for 4 hours, filtered, and the filtrate was combined; safflower was added with 20 times the amount of water, extracted 3 times, each time for 40 minutes, Filter and combine the filtrates; mix the Aconitum aconitum extract and the safflower extract and concentrate to a thick paste with a relative density of 1.50 (50°C). Mix ephedra and geranium evenly, add 20 times the amount of 95% ethanol, reflux extraction 4 times, each time for 3 hours, filter, combine the filtrate and concentrate to a thick paste with a relative density of 1.50 (50°C), and store at 50°C, -0.08 Under the condition of Mpa, it is dried under vacuum and reduced pressure to be a dry paste. Add 20 times the amount of 95% ethanol to the Sperantoides, ext...

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Abstract

The invention relates to an external preparation for treating a rheumatism pain disease, and a preparation method thereof. The external preparation is prepared from five traditional Chinese medicines, namely prepared monkshood, ephedra, flowers carthami, geranium wilfordii and phryma leptostachya. The traditional Chinese medicines are prepared into general granular preparation or effervescent granule preparation or effervescent tablet by extracting, concentrating and adding auxiliary materials. The preparation disclosed by the invention is used for treating rheumatic and rheumatoid diseases such as rheumatism pain, arthralgia, injury from falling down, aching muscles, ulcer pyogenic infections and the like, has the effects of dispelling wind and eliminating dampness, warming channel and expelling cold, promoting blood circulation to remove blood stasis, detoxifying and stopping pain, and is significant in effect, easy to absorb, and high in bioavailability. A modern extracting technology and a molding technology are adopted according to the characteristics of effective ingredients in each medicament; the effect of each medicament is fully played; the utilization rate of the medicament is increased; the medicaments are saved; the external preparation is complete in product quality control, stable in property, and convenient to use and carry; and the process can achieve the targets of industrial production and mechanical package.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, specifically, a traditional Chinese medicine preparation which has the functions of expelling wind and dehumidification, warming the meridian and dispelling cold, promoting blood circulation and removing blood stasis, detoxifying and relieving pain, and can be used to treat rheumatic arthralgia, joint pain, injury from falling, sore muscles and bones, sores and swollen skin. Drugs for external use mainly for rheumatic arthralgia and other rheumatism diseases, as well as preparation methods and applications thereof. Background technique [0002] Rheumatism refers to a group of diseases mainly caused by muscle and joint pain, mainly affecting the connective tissue of the body, which may be caused by damage to the immune system. Traditional Chinese medicine believes that it is caused by wind, cold, dampness, heat and other exogenous evils invading the human body and blocking the meridian...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/16A61K9/46A61P29/00
Inventor 杨官娥薛强强郑庆红韩宝龙田俊杰
Owner SHANXI MEDICAL UNIV
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