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Amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound and preparation method thereof

A technology of isopropyl acrylamide europium and amino porphyrin, which is applied in the field of an amino porphyrin-poly-N-isopropyl acrylamide europium complex and its preparation, and can solve the problems of cytotoxicity, poor water solubility and the like , to achieve the effect of less toxic and side effects

Inactive Publication Date: 2013-04-24
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, TPP including HpD has poor water solubility and cytotoxicity, and will form systemic distribution after entering the human body

Method used

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  • Amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound and preparation method thereof
  • Amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound and preparation method thereof
  • Amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound and preparation method thereof

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Embodiment Construction

[0018] Aminoporphyrin-poly N-isopropylacrylamide europium complex of the present invention ((NH 2 ) n -TPP-PNIPAM-Eu(Ⅲ)-TTA) The preparation method specifically includes the following steps: first, adopt the Adler method to synthesize tetraphenylporphyrin TPP, and obtain aminotetraphenylporphyrin (NH 2 ) n -TPP, n=1,2,3, referred to as aminoporphyrin; secondly, aminoporphyrin is prepared into ATRP initiator with α-haloacyl halide (NH 2 ) n -TPP-X, n=1,2,3, where X is a halogen; third, NIPAM polymerization of N-isopropylacrylamide monomer initiated by ATRP initiator in Cu(I)X / organic ligand catalyst system , where X is a halogen, yielding the polymer (NH 2 ) n -TPP-PNIPAM, n=1,2,3; Finally, the polymer is complexed with the organic small molecule ligand α-thienoyltrifluoroacetone TTA and the rare earth europium Eu to obtain the complex (NH 2 ) n -TPP-PNIPAM-Eu(III)-TTA.

[0019] The technical effect of each step of the method is that from tetraphenylporphyrin TPP to ami...

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Abstract

The invention discloses amino porphyrin-poly (N-isopropylacrylamide) europium coordination compound and a preparation method of the amino porphyrin-poly (N-isopropylacrylamide) europium coordination compound. The preparation method of the amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound is characterized in that (NH2)n-TPP is prepared into an ATRP initiator which is NH2-TPP-X, wherein the X is halogen. The NH2-TPP-X is adopted to initiate NIPAM to be polymerized to obtain polymer which is (NH2)n-TPP-PNIPAM. The europium with tervalence is coordinated with the polymer (NH2)n-TPP-PNIPAM to obtain coordination compound which is (NH2)n-TPP-PNIPAM-Eu(III)-TTA through the TTA, wherein the n meets an equation that is n=1,2,3. The amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound is characterized in that a short form of the amino porphyrin- poly (N-isopropylacrylamide) europium coordination compound is (NH2)n-TPP-PNIPAM-Eu(III)-TTA, wherein the TPP is tetraphenylporphyrin, wherein the shortened form of the tetraphenylporphyrin is porphyrin, the PNIPAM is the poly (N-isopropylacrylamide), the Eu(III) is the europium with the tervalence, and the TTA is alpha- thenoyltrifluoroacetone.

Description

technical field [0001] The invention relates to an aminoporphyrin-poly-N-isopropylacrylamide europium complex and a preparation method thereof. The complex is a tumor-targeting and temperature-sensitive compound with a macrocyclic conjugated structure Macromolecular compounds make use of the acidic environment sensitivity of aminoporphyrin to enrich it near the tumor tissue during in vivo circulation, and then irradiate the tumor target site with 405nm or 630nm wavelength laser to excite the porphyrin and promote the generation of active oxygen , which kills cancer cells, and belongs to the technical field of macromolecular photodynamic therapy. Background technique [0002] PDT (photodynamic therapy, photodynamic therapy) is a new method for treating malignant tumors developed in the past 20 years. Now, PDT has also received extensive attention in the treatment of non-tumor diseases, and in the near future it will become an effective means of treating stubborn diseases suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/54C08F8/42A61K41/00A61P35/00C09K11/06
Inventor 段潜杨扬李艳辉常晶晶
Owner CHANGCHUN UNIV OF SCI & TECH
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