Procationic/ cationic liposome curcumin preparation for interventional treatment of hepatic carcinoma and preparation method of preparation

Abstract

The invention relates to a procationic / cationic liposome curcumin preparation for interventional treatment of hepatic carcinoma and a preparation method of the preparation. The preparation consists of curcumin and multiple components which can be pharmaceutically prepared into a procationic / cationic liposome carrier. The preparation is mainly prepared from the following raw materials in percentage by weight: 0.001 to 5 percent of curcumin, and 95 to 99.999 percent of procationic / cationic liposome carrier. The cationic liposome curcumin preparation is prepared from egg yolk lecithin, cholesterol, octadecyl amine, vitamin E, ether, anhydrous ethanol, curcumin and the like by adopting a film dispersion method. The procationic liposome curcumin preparation is prepared from egg yolk lecithin, cholesterol, [2-[[4-[(carboxymethyl) dithio]-1-imidobutyl] amino] ethyl] carbamic acid cholesteryl ester (CHETA), vitamin E, ether, anhydrous ethanol, curcumin and the like by adopting the film dispersion method. The preparation for the interventional treatment of the hepatic carcinoma is efficient and safe.

Description

Technical field: [0001] The invention belongs to the field of new drug development of traditional Chinese medicines, and in particular relates to a procation / cation liposome curcumin preparation for interventional treatment of liver cancer and a preparation method thereof. Background technique: [0002] Primary liver cancer (primary carcinoma of the liver) is a cancer that originates from hepatic parenchymal cells or intrahepatic cholangiocytes, and hepatocellular carcinoma (HCC) is the most common clinical form. Because of its insidious onset, rapid development, and high mortality rate, it is commonly known as the "king of cancer" and has become an enemy that threatens human health. Liver cancer is the fifth most common malignant tumor and the third most common cause of cancer death in the world. my country is one of the high incidence areas of liver cancer, about 50% of which occur in China. [0003] Surgery, radiation therapy (radiotherapy), and chemotherapy (chemotherap...

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Problems solved by technology

[0010] In order to solve the problems of poor long-term curative effect and high toxicity in the existing interventional preparations for the treatment of liver cancer, this patent uses curcumin, an edible and non-toxic active ingredient in turmeric, an anticancer traditional Chinese medicine, as interventional therapy Combining it with liposomes and intervening in the treatment of liver cancer can well solve the above problems