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Fluoro-calcium silicate biological ceramic material and preparation method and application thereof

A bioceramic material, the technology of calcium fluoride-based silicate, which can be used in applications, other household appliances, dental preparations, etc., can solve the problems of inducing apatite, etc., and achieve the effect of simple production and good biological activity.

Active Publication Date: 2013-04-10
四川亿诺森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The conventional method is to add sodium fluoride to the toothpaste formula, but the simple release of fluoride ions and other elements in the formula cannot form active substances and induce the formation of apatite

Method used

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  • Fluoro-calcium silicate biological ceramic material and preparation method and application thereof
  • Fluoro-calcium silicate biological ceramic material and preparation method and application thereof
  • Fluoro-calcium silicate biological ceramic material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Take 236 grams (1 mole) of calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) (analytically pure) was dissolved in 5000 ml of deionized water to make a solution, and stirred on a magnetic stirrer, and 284 grams (1 mole) of sodium silicate nonahydrate (Na 2 SiO 3 9H 2 O) (analytical grade) and 2.96 g (0.08 mol) of ammonium fluoride (NH 4 F) (analytical pure) made into a mixed solution,

[0029] (2) Slowly add the mixed solution to the calcium nitrate solution at 15 drops per minute, stir while dripping, continue stirring for 1 hour after dropping, and then age at room temperature for 24 hours.

[0030] (3) Filter out the supernatant, wash the precipitate with deionized water for 3 times, dehydrate with ethanol for 3 times, and then dry it in an oven at 70°C for 24 hours;

[0031] (4) Calcining the dried white powder at 700°C for 2 hours to obtain calcium fluoride silicate powder.

[0032] Take the fluorine-containing calcium silicate powder sample prepared abov...

Embodiment 2

[0041] (1) Take 111 grams (1 mole) of calcium chloride (CaCl 2 ) (analytically pure) was dissolved in 5000 ml of deionized water to make a solution, and stirred on a magnetic stirrer, and 117 grams (0.96 moles) of sodium silicate (Na 2 SiO 3 ) (analytical pure) and 0.84 g (0.02 mol) sodium fluoride (NaF) (analytical pure) to make a mixed solution,

[0042] (2) Slowly add the mixed solution to the calcium nitrate solution at 15 drops per minute, stir while dripping, continue stirring for 1.5 hours after the dripping, and then age at room temperature for 22 hours.

[0043] (3) Filter out the supernatant, wash the precipitate with deionized water for 3 times, dehydrate with ethanol for 3 times, and then dry it in an oven at 70°C for 24 hours;

[0044] (4) Calcining the dried white powder at 650°C for 2.2 hours to obtain fluorine-containing calcium silicate powder.

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Abstract

The invention discloses a fluoro-calcium silicate biological ceramic material and a preparation method and application thereof. The fluoro-calcium silicate biological ceramic material is prepared by dipping mixed solution prepared by sodium silicate and alkali fluoride into calcium salt solution to generate precipitates, and filtering, washing, drying and forging the precipitates. The molar ratio of sodium silicate and fluoride is proportioned to prepare the fluoro-calcium silicate biological ceramic material with different fluorine-containing contents. Compared with the traditional sodium silicate biological ceramic, the prepared fluoro-calcium silicate biological ceramic has the advantage that bone-like apatite can be rapidly formed in a simulated body liquid environment, and can be used as a toothpaste additive and a hard tissue defect repairing material.

Description

technical field [0001] The invention relates to a fluorine-based calcium silicate bioceramic material and a preparation method and application thereof, belonging to the field of biomaterials. Background technique: [0002] Human teeth are the densest inorganic biominerals in hard tissues, and the inorganic substances account for more than 95% of the chemical composition, mainly nano-hydroxyapatite. Although a small amount of fluorine in teeth can resist acid erosion to a certain extent, when teeth are in contact with acidic media for a long time, hydroxyapatite will be dissolved by acid to generate hydrogen phosphate ions and calcium ions, which will be washed away by saliva, resulting in The breakdown of tooth tissue produces caries. [0003] Calcium-silicon-based bioactive ceramics can induce mineralization in vivo to form bone-like apatite [(1) J Biomed Mater Res 2000,52:30. (2) J Mater Sci: Mater Med 2005,16:73 ], which The chemical composition is similar to that of hu...

Claims

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Application Information

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IPC IPC(8): C04B33/16C04B35/626A61K6/027A61K8/25A61Q11/00
Inventor 董志红
Owner 四川亿诺森生物科技有限公司
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