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Preparation method of thiazole compounds

A compound and thiazole-based technology, applied in the field of preparation of thiazole-based compounds, can solve the problems of unfavorable industrial production and environmental protection, expensive raw materials, high price of finished products, etc., and achieve the advantages of industrial production and environmental protection, simple post-processing, solvent The effect of consumption saving

Inactive Publication Date: 2013-04-03
SHANGHAI INST OF PHARMA IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The technical problem to be solved by the present invention is: in order to overcome the existing reaction of preparing 4-alkyl-5-alkoxyformylthiazole, the molar volume of the reaction is too large, there are many by-products, the yield is low, the post-treatment is complicated, and the raw material The high price of the finished product caused by the high price is not conducive to the defects of industrialized production and environmental protection, and a preparation method of 4-alkyl-5-alkoxyformylthiazole and 4-alkyl-5-formylthiazole is provided

Method used

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Examples

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Embodiment 1

[0036] Example 1 Preparation of tert-butyl nitrite

[0037] Add 38.0g (0.55mol) sodium nitrite and 150ml water in the 250ml three-necked reaction bottle that agitator and thermometer are housed, the reaction bottle is placed in ice-salt bath and stirred, the solution temperature is down to 0 ℃. Mix 10ml of water, 13.6ml (25.0g, 0.25mol) of 98% concentrated sulfuric acid (density 1.84g / ml), 45.7ml of tert-butanol (37.0g, 0.5mol) and pre-cool to 0°C, then slowly Add it dropwise to the above sodium nitrite solution, control the temperature at ±1°C, the whole dropping process takes 1-1.5h, and react for 1-2h after the dropping.

[0038] After the reaction was completed, the mixture was placed under an ice-salt bath and the layers were separated. The solution was poured into a separatory funnel to remove a small amount of solid sodium sulfate, and the upper light yellow organic layer was separated. The organic layer was washed twice with 100ml aqueous solution containing 2g sodium...

Embodiment 2

[0039] Embodiment 2 Preparation of n-butyl nitrite

[0040] Add 38g of sodium nitrite and 150ml of water into a 250ml three-necked bottle, dissolve and cool down to -5-0°C. Mix 10ml of water, 13.6ml (25.0g, 0.25mol) of 98% concentrated sulfuric acid (density 1.84g / ml) and 37.0g of n-butanol, pre-cool to 0°C, and then slowly add it dropwise to the above nitrous acid In sodium solution, keep the temperature at 0°C. After dropping, continue to stir in an ice bath for 1h. Then the reaction solution is poured into a 250ml separating funnel, layered, and the light yellow liquid organic phase of the upper floor is separated, and the organic phase is washed twice with 100ml of aqueous solution containing 2.0g sodium bicarbonate and 25.0g sodium chloride (each 50ml ), then the organic layer was separated, dried with anhydrous sodium sulfate, and filtered to obtain 45.1 g of light yellow liquid which was n-butyl nitrite, with a yield of 87.6%.

Embodiment 3

[0041] Example 3 Preparation of 4-methyl-5-ethoxyformylthiazole

[0042] Add 0.78g (7.5mmol) tert-butyl nitrite and 7ml of anhydrous N,N-dimethylformamide to a 50ml three-neck flask equipped with a stirrer, a thermometer and a reflux condenser with a sealed balloon, and heat up to 65°C under stirring. -70°C. Dissolve 0.93g (5.0mmol) of 2-amino-4-methyl-5-ethoxyformylthiazole in 3ml of anhydrous N,N-dimethylformamide, then slowly add it dropwise to the above solution, drop The addition process takes about 5 minutes, the temperature is controlled at 60-70°C, and the sealed balloon shows that there is gas generation in the reaction. After 30min, TLC showed that the starting material disappeared substantially (the developing solvent was cyclohexane:ethyl acetate 3:1, R f value is around 0.6). The reaction solution turned from light yellow to dark red. Lower the reaction solution to 0-5°C in an ice bath, add 50ml of water and 50ml of ethyl acetate under stirring, separate the u...

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Abstract

The invention provides a preparation method of a thiazole compound as shown in a formula II, comprising the following steps of: by taking alkyl nitrite R3NO2 as a diazotization reagent, performing a diazotization deamination reaction on a compound of a formula I in an anhydrous polar solvent at a reaction temperature of 30-80 DEG C to generate the compound as shown in the formula II. The invention further provides a preparation method of a thiazole compound shown in a formula IV, comprising the following steps of: converting an ester group in the compound of the formula II to an aldehyde group so as to prepare the compound shown as the formula IV. The preparation method provided by the invention is moderate in reaction conditions, simple and convenient to operate, few in by-products, small in reaction molar volume, simple in after-treatment, saved in solvent dosage, suitable for industrialized production, environment-friendly, and capable of preparing the high-yield and high-purity key intermediate, namely, 4-methyl-5-formoxyl thiazole, of cefditoren pivoxil.

Description

technical field [0001] The invention relates to the field of drug synthesis, in particular to a preparation method of thiazole compounds (4-alkyl-5-alkoxyformylthiazole and 4-alkyl-5-formylthiazole). Background technique [0002] 4-Methyl-5-formylthiazole is an important side chain for the synthesis of the third-generation cephalosporin antibacterial drug cefditoren pivoxil, and their molecular structures are as follows Formula IV Compound, Formula V Compound. Cefditoren axetil was developed by Meiji Seika Co., Ltd., and was listed in Japan under the trade name of Meiact in 1994. Cefditoren axetil has a broad antibacterial spectrum against Gram-positive and Gram-negative bacteria. The patent expired in 2004 and has no administrative protection in China. [0003] [0004] Japanese literature Chemical and Pharmaceutical Bulletin; Vol.39; nb.9; (1991); The starting materials were used in the reactions. [0005] Document Journal of Organic Chemistry; vol.25; (1960); p.133...

Claims

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Application Information

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IPC IPC(8): C07D277/56C07D277/24
Inventor 姜碧波黄成军何建勋
Owner SHANGHAI INST OF PHARMA IND
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