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Method for preparing Bailing tablets and application

A technology of Bailing tablets and tissue cells, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large dosage, backwardness, and many impurities for patients, and achieve the effect of reducing dosage

Inactive Publication Date: 2013-12-25
李宽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Bailing Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Method for preparing Bailing tablets and application
  • Method for preparing Bailing tablets and application

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Take 194g of angelica, 42g of Sanqi, 83g of safflower, 167g of peony bark, 83g of peach kernel, 167g of windproof, 167g of herb, 42g of Angelica dahurica, 417g of purslane, 83g of red peony, and 194g of astragalus. Added to the CO2 supercritical extractor, ethanol is used as entrainer, the entrainer accounts for 4% by volume of the total extraction solvent, extraction pressure is 15MPa, temperature is 30°C, CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, the extraction power is 400W, and the extraction is performed twice, Combine the extracts for 4 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pre...

Embodiment 2

[0028] Take 194g of angelica, 42g of Sanqi, 83g of safflower, 167g of peony bark, 83g of peach kernel, 167g of windproof, 167g of herb, 42g of Angelica dahurica, 417g of purslane, 83g of red peony, and 194g of astragalus. Join to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol unde...

Embodiment 3

[0031] Take 194g of angelica, 42g of Sanqi, 83g of safflower, 167g of peony bark, 83g of peach kernel, 167g of windproof, 167g of herb, 42g of Angelica dahurica, 417g of purslane, 83g of red peony, and 194g of astragalus. Join to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol unde...

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Abstract

The invention provides a method for preparing Bailing tablets. The Bailing tablets are prepared from 194g of Chinese angelica, 42g of pseudo-ginseng, 83g of safflower, 167g of peony bark, 83g of peach kernel, 167g of divaricate saposhnikovia root, 167g of atractylodes, 42g of angelica root, 417g of purslane, 83g of red peony root and 194g of astragalus root serving as raw medicaments by adopting supercritical extraction and microwave extraction, so that the ferulic acid content is greatly improved. The invention also provides application of the Bailing tablets in preparation of a medicament for inhibiting propagation of human histiocytic lymphoma U937 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Bailing tablets. Background technique [0002] Bailing tablets are recorded in the standard WS3-B-0914-91 of the Ministry of Health, consisting of 194g of angelica, 42g of Sanqi, 83g of safflower, 167g of Moutan bark, 83g of peach kernel, 167g of Fangfeng, 167g of atractylodes, 42g of Angelica dahurica, 417g of purslane, 83g of Paeoniae Alba and 194g of Astragalus are made as raw materials, which can promote blood circulation and remove blood stasis, and increase photosensitivity. For Vitiligo. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Bailing Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/20A61P35/00
Inventor 李宽李少博
Owner 李宽
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