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Preparation method and application of bone-knitting tablet

A kind of bone bone slices and the technology of making Aconitum aconitum, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, bone diseases, etc., can solve the problems of rough technology, backwardness, and large dosage of patients

Inactive Publication Date: 2013-03-27
张鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of bone joint tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Preparation method and application of bone-knitting tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 39g of Rhizoma Chuanxiong, 39g of Zhichuanwu, 39g of Angelica, 39g of Vinegar-roasted Frankincense, 39g of Vinegar-roasted Myrrh, and 39g of Calcined Natural Copper. , ethanol as entrainer, entrainer accounted for 4% of the volume of the total extraction solvent, extraction pressure 15MPa, temperature 30 ° C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction is performed twice. Combine extracts for 4 minutes each time, concentrate, add to D102 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , set aside; mix the above supercritical extrac...

Embodiment 2

[0028] Take 39g of Chuanxiong, 39g of Zhichuanwu, 39g of Angelica, 39g of vinegar-roasted frankincense, 39g of vinegar-roasted myrrh, and 39g of calcined natural copper, and add Chuanxiong, angelica, vinegar-roasted frankincense, and vinegar-roasted myrrh 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. For 8 minutes each time, combine the extracts, concentrate, add to D102 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recov...

Embodiment 3

[0031] Take 39g of Chuanxiong, 39g of Zhichuanwu, 39g of Angelica, 39g of vinegar-roasted frankincense, 39g of vinegar-roasted myrrh, and 39g of calcined natural copper, and add Chuanxiong, angelica, vinegar-roasted frankincense, and vinegar-roasted myrrh 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D102 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate...

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Abstract

The invention provides a preparation method of a bone-knitting tablet. The bone-knitting tablet is prepared by using 39g of szechuan lovage rhizome, 39g of radix aconiti preparata, 39g of Chinese angelica, 39g of frankincense stir-fried with vinegar, 39g of myrrh stir-fried with vinegar and 39g of forged natural coppers as bulk drugs and adopting supercritical extraction and microwave-assisted extraction modes. By adopting the method, the content of ferulic acid is greatly improved; and the invention also provides application of the bone-knitting tablet in preparation of drugs for inhibiting cell proliferation of mice leukemia cell NFS-60.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of osteosynthetic tablets. Background technique [0002] The bone joint tablets are recorded in the standard WS3-B-0402-90 of the Ministry of Health, and are made from 39g of Rhizoma Chuanxiong, 39g of Aconitum Aconitum, 39g of Angelica, 39g of Vinegar-roasted Frankincense, 39g of Vinegar-roasted Myrrh, and 39g of Calcined Natural Copper. Blood stasis, promoting blood circulation, relieving pain, used for bruises, tendon injuries and fractures, blood stasis, swelling and pain. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of bone joint tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/20A61P35/02A61P19/08A61P29/00A61K33/26
Inventor 不公告发明人
Owner 张鹏
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