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Preparation method and application of nose comforting tablet

An extraction technology for sharp nose tablets, applied in the field of preparation of sharp nose tablets, can solve the problems of large dosage for patients, affect clinical application, and many impurities, and achieve the effect of reducing the dosage

Active Publication Date: 2013-03-27
海门江海建设投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of beneficial nasal tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Preparation method and application of nose comforting tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 100g of scutellaria baicalensis, 150g of cocklebur seed, 100g of cocklebur, 75g of mint, 100g of dahurian root, 25g of asarum, and 500g of bog worm, add scutellaria, mint, and asarum into the CO2 supercritical extractor. Ethanol is used as entrainer and entrainer The volume percentage of the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 150min. The supercritical extract is obtained for use; take the rest of the traditional Chinese medicine, crush, and add 2L of 70 % Ethanol, put into microwave extraction device for microwave extraction, extraction power 400W, extraction 2 times, 4 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, 50% ethanol elution, collect 5 times Measure the column volume of the eluent, recover ethanol under reduced pressure, concentrate and dry to obtain a microwave extract for use...

Embodiment 2

[0028] Take 100g of scutellaria baicalensis, 150g of cocklebur seed, 100g of Xinyi, 75g of mint, 100g of dahurian, 25g of asarum, and 500g of bog Ying, add Xinyi, mint, and asarum to CO 2 In the supercritical extractor, ethanol is used as the entrainer, and the entrainer accounts for 6% of the total extraction solvent. The extraction pressure is 30MPa, the temperature is 50°C, and CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; take the rest of the traditional Chinese medicine, crush it, add 2L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. For 8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, eluted with 50% ethanol, collect 5 times the column volume of the eluate, recover the ethanol under reduced pressure, concentrate and dry to obtain...

Embodiment 3

[0031] Take 100g of scutellaria baicalensis, 150g of cocklebur seed, 100g of Xinyi, 75g of mint, 100g of dahurian, 25g of asarum, and 500g of bog Ying, add Xinyi, mint, and asarum to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 5% of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; take the remaining traditional Chinese medicine, crush it, add 2L of 70% ethanol, and put it into the microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. For 6 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, eluted with 50% ethanol, collect 5 times the column volume of the eluate, recover the ethanol under reduced pressure, concentrate and dry to obtain the...

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Abstract

The invention provides a preparation method of a nose comforting tablet which is prepared from crude drugs including 100g of scutellaria baicalensis, 150g of Fructus Xanthii, 100g of violet magnolia, 75g of mint, 100g of radix angelicae, 25g of asarum, and 500g of dandelion through supercritical extraction and microwave extraction, so that the content of baicalein is greatly improved. The invention also provides the application of the nose comforting tablet in preparing a medicine for restraining proliferation of human melanoma cell, M14 cell.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a nasal benefit tablet. Background technique [0002] Libi Tablets are recorded in the Ministry of Health Standard WS3-B-0746-91. They are made of 100g Scutellaria baicalensis Georgi, 150g Cocklebur Seed, 100g Xinyi 100g, Mint 75g, Angelica dahurica 100g, Asarum 25g, and 500g Bogong Ying as raw materials. It can clear away heat and detoxify. , Qufeng resuscitation. Used for nasal cavity, nasal congestion and runny nose. [0003] In the prior art, there has not been a report on the use of supercritical and microwave technology in the extraction and preparation of beneficial nose tablets. However, the method of powdering and decoction is used, the process is rough, backward, and there are many impurities, which causes the patient to use too much and is inconvenient to take. It seriously affected the clinical appli...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K9/20A61P11/02A61P35/00
Inventor 不公告发明人
Owner 海门江海建设投资有限公司
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