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Method for extracting total saponin from kalopanax septemlobus leaves

A technology for total saponins and C. chinensis leaves, which is applied in the field of extracting total saponins from C. chinensis leaves by using membrane separation technology, can solve the problems of low product content, product pollution and high cost, achieves low energy consumption, and solves the problem of easy foaming. Effect

Inactive Publication Date: 2013-02-06
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned above, the macroporous resin pollutes the product solution and the product, and the single extraction method has low product content and high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Dry and pulverize the leaves of Cinnamon chinensis, take 10kg, add 10 times 50% ethanol and warm soak at 60°C for 3 hours, extract twice, filter the extract to recover ethanol, add appropriate amount of deionized water to the concentrate, filter, add hollow Ultrafiltration in the cellulose ultrafiltration membrane system, the permeate is added to a hollow cellulose nanofiltration membrane system with a molecular weight cut-off of 800 to concentrate, the concentrated solution is added to an equal volume of ethyl acetate to extract 3 times, and the extract is passed through neutral alumina (120 -200 mesh) short column, collect the lower column liquid to recover the reagent, and the concentrated solution is spray-dried to obtain 320 g of off-white total saponins, with a content of 90.3% (UV method).

Embodiment 2

[0016] Dry and pulverize the leaves of Cinnamon chinensis, take 10kg, add 6 times of 90% ethanol and soak at 50°C for 2 hours, extract 3 times, filter the extract to recover ethanol, add appropriate amount of deionized water to the concentrate, filter, add hollow Ultrafiltration in the cellulose ultrafiltration membrane system, the permeate is added to a hollow cellulose nanofiltration membrane system with a molecular weight cut-off of 600 to concentrate, the concentrated solution is added to an equal volume of ethyl acetate to extract 3 times, and the extract is passed through neutral alumina (120 -200 mesh) short column, collect the lower column liquid to recover the reagent, and the concentrated solution is spray-dried to obtain 384 g of off-white total saponins, with a content of 83.7% (UV method).

Embodiment 3

[0018] Dry and pulverize the leaves of Cinnamon chinensis, take 10kg, add 8 times of 80% ethanol and warm soak at 50°C for 3 hours, extract twice, filter the extract to recover ethanol, add appropriate amount of deionized water to the concentrate, filter, add hollow Ultrafiltration in the cellulose ultrafiltration membrane system, the permeate is added to a hollow cellulose nanofiltration membrane system with a molecular weight cut-off of 700 to concentrate, the concentrated solution is added to an equal volume of ethyl acetate to extract 3 times, and the extract is passed through neutral alumina (120 -200 mesh) short column, collect the lower column liquid to recover the reagent, and the concentrated solution is spray-dried to obtain 353 g of off-white total saponins, with a content of 86.3% (UV method).

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Abstract

The invention discloses a method for extracting total saponin from kalopanax septemlobus leaves. The method comprises the steps that: kalopanax septemlobus leaves are dried and crushed; 6-10 times of 50-90% ethanol are added for carrying out warm-soaking extraction 2-3 times; an obtained extraction liquid is filtered, and ethanol is recovered; a proper amount of deionized water is added into the concentrate; the mixture is filtered, and is subjected to ultrafiltration in an ultrafiltration membrane system; a permeate is concentrated in a nano-filtration membranes system; ethyl acetate is added into the concentrate for extracting; an extraction liquid is processed by using a aluminum oxide short column; a reagent in off-column liquid is recovered; and spray-drying is carried out, such that the total saponin is obtained. The method provided by the invention has the advantages of simple process, easy operation, low production energy consumption, high product quality, and suitability for industrialized production.

Description

technical field [0001] The invention relates to a method for extracting total saponins from the leaves of thorn tree leaves, in particular to a method for extracting total saponins from the leaves of thorn tree leaves by using membrane separation technology. Background technique [0002] Prickly catalpa is a plant of Araliaceae, also known as Niaobusu, nail wood tree, Dingtong bark, and its roots, root bark or bark are used as medicine. Pungent in nature and flavor, flat, has expelling wind and promoting dampness, promoting blood circulation and relieving pain. It is often used to treat rheumatism, waist and knee pain, nephritis, edema, bruises, and internal hemorrhoids with blood in the stool. Modern studies have shown that the bark of Chinese thorn contains thorny bark saponins, alkaloids, tannins and flavonoids, and studies have also found that the pharmacological effects of saponins in thorny catalpa are mainly anti-tumor, antibacterial and anti-inflammatory activities,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61P3/10A61P29/00A61P31/04A61P35/00A61K127/00
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司
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