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Parapoxvirus expressing the vp60 major capsid protein of the rabbit haemorrhagic disease virus

A technology of the main capsid protein, rabbit hemorrhagic fever virus, applied in the field of therapeutic agents

Inactive Publication Date: 2013-01-23
RIEMSER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] However ORFV has not been used in rabbits or as a vaccine against RHDV

Method used

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  • Parapoxvirus expressing the vp60 major capsid protein of the rabbit haemorrhagic disease virus
  • Parapoxvirus expressing the vp60 major capsid protein of the rabbit haemorrhagic disease virus
  • Parapoxvirus expressing the vp60 major capsid protein of the rabbit haemorrhagic disease virus

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Embodiment Construction

[0031] In one aspect, the present invention relates to a recombinant parapox virus containing a DNA sequence encoding the major capsid protein of RHDV VP60. According to the present invention, this recombinant parapoxvirus expresses the gene product of the VP60 gene. The specific open reading frame of VP60 is inserted into the parapox virus vector, and the resulting recombinant virus is used to immunize animals. The expression of the VP60 gene product results in an immune response specifically directed to VP60 in the treated animals. Therefore, the recombinant virus of the present invention can be used in immunological compositions or vaccines to provide a means for inducing an immune response, which can be, but need not be protective. The immune response may be therapeutic or preventive in terms of its effect.

[0032] The combination of VP60 and parapox virus enables VP60-containing virus to be produced in cell culture, which has not been successfully achieved until now. The...

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Abstract

The invention describes a therapeutic agent capable of treating and / or preventing rabbit haemorrhagic disease virus infection in rabbits, namely a recombinant parapoxvirus, characterized in that the VP60 major capsid protein from the rabbit haemorrhagic disease virus (RHDV) is expressed from a foreign nucleic acid.

Description

[0001] description [0002] The present invention relates to a therapeutic agent capable of treating and / or preventing rabbit hemorrhagic fever virus infection in rabbits, that is, a recombinant parapox virus characterized in that VP60 from rabbit hemorrhagic fever virus (RHDV) is expressed by foreign nucleic acid. Capsid protein. Background technique [0003] Rabbit hemorrhagic fever virus (RHDV) is a highly contact disease in hares and domestic rabbits (such as the European hare species (Oryctolagus cuniculus)). It was first reported in the People's Republic of China in 1984. RHDV subsequently spread throughout Europe between 1987 and 1989. Infected adult rabbits usually die of necrotizing hepatitis and hemorrhagic syndrome within 48 to 72 hours after infection. Morbidity and mortality in the population can be as high as 90-100%. [0004] This disease is the cause of severe economic losses in commercial rabbit production and high mortality in hares. The production of commercial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12C07K14/08
CPCA61K2039/5256C12N2770/16034A61K39/12A61K2039/5254C12N2770/16022C07K14/005C12N7/00C12N15/86C12N2710/24243C07K14/08A61K45/06A61K2039/552
Inventor 阿希姆·日哈
Owner RIEMSER PHARMA
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