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Novel pranoprofen eye drop and preparation method thereof

A technology of eye drops and excipients, which is applied in the field of medicine and can solve problems such as the report of pranoprofen eye drops without adding carbomer

Inactive Publication Date: 2013-01-23
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, domestic pranoprofen eye drops have been listed, but there is no report of pranoprofen eye drops with carbomer

Method used

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  • Novel pranoprofen eye drop and preparation method thereof
  • Novel pranoprofen eye drop and preparation method thereof
  • Novel pranoprofen eye drop and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation method:

[0023] Get pranoprofen and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0024] Take the prescribed amount of carbomer in water for injection, stir continuously at 80-90°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0025] Slowly add the filtered carbomer solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clarified solution, sub-package, quality test, and pass the test.

Embodiment 2

[0027] prescription:

[0028]

[0029] Preparation method:

[0030] Get pranoprofen, sodium chloride, boric acid and relevant auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0031] Take the prescribed amount of carbomer in water for injection, stir continuously at 80-90°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0032] Slowly add the filtered carbomer solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clarified solution, sub-package, quality test, and pass the test.

Embodiment 3

[0034] prescription:

[0035]

[0036] Preparation method:

[0037] Get pranoprofen, sodium chloride, boric acid and relevant auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0038] Take the prescribed amount of carbomer in water for injection, stir continuously at 80-90°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0039] Slowly add the filtered carbomer solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clarified solution, sub-package, quality test, and pass the test.

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Abstract

The invention discloses a novel pranoprofen eye drop and a preparation method thereof. The preparation method of the eye drop disclosed by the invention comprises the steps of: dissolving pranoprofen and relevant accessories in water; adding a swelling carbomer aqueous solution to the liquid medicine and then uniformly stirring; adding a sufficient amount of water; and finally, filtering and dispensing to obtain the eye drop. According to the novel pranoprofen eye drop and the preparation method thereof, the defects of the current pranoprofen eye drop are overcome; the residence time of the medicine on ocular surface is prolonged by the physical thickening and moisturizing lubrication effects of carbomer; and furthermore, the medicine seldom flows into mouth and nasal cavity so as to reduce medicine loss and avoid bitterness from the pranoprofen eye drop, and therefore, compliance of patients is increased and clinical curative effect is ensured.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and discloses a new pranoprofen eye drop and a preparation method thereof. Background technique: [0002] Pranoprofen, chemical name: 2-(5H-[1]benzopyran[2,3-b]pyridin-7-yl)propionic acid, chemical structural formula: [0003] [0004] Molecular formula: C 15 h 13 NO 3 , molecular weight: 255.27. [0005] Pranoprofen is an anti-inflammatory drug developed by Welfide Company (i.e. former Jifu Pharmaceutical Co., Ltd.) (now Mitsubishi Pharmaceuticals), and it was listed in Japan under the trade name Niflan in 1981. [0006] Prostaglandins have a wide range of local effects on various tissues, especially when inflammatory reactions occur, they can be found in various animals and human bodies, and are relatively important substances in inflammatory reactions. Physical and chemical trauma to the eye, surgery, anterior chamber puncture, laser irradiation, and stimulation of the trigeminal ner...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/436A61K47/32A61P27/02
Inventor 魏福荣陈进陈杨芳许亦男吴修艮
Owner JIANGSU JIBEIER PHARMA
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