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Device and method for preparing pulsatile release microspheres

A pulse release and preparation device technology, which is applied in the direction of microsphere preparation, microcapsule preparation, etc., can solve the problem that microspheres cannot exhibit pulse release behavior, and achieve strong controllability of release behavior, simple operation, and uniform particle size Effect

Inactive Publication Date: 2013-01-02
ZHEJIANG PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, microspheres prepared by existing preparation techniques such as emulsified solvent diffusion method, emerging membrane emulsification technology, and microfluidic technology cannot yet exhibit pulsed drug release behavior.

Method used

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  • Device and method for preparing pulsatile release microspheres
  • Device and method for preparing pulsatile release microspheres
  • Device and method for preparing pulsatile release microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the preparation device of pulse release microsphere such as figure 1 As shown, it includes: constant flow pump 1 , constant flow pump 2 , constant flow pump 3 , coaxial nozzle 4 , frequency generator 5 , signal amplifier 6 , ultrasonic transducer 7 , collection container 8 and agitator 9 . The coaxial nozzle 4 is a concentric three-port nozzle, wherein the inner diameter of the inner nozzle is 100 μm It is also connected to the constant flow pump 1 through an independent liquid delivery pipeline, and the inner diameter of the middle nozzle is 200 μm It is connected with the constant flow pump 2 through an independent liquid delivery pipeline, and the inner diameter of the outer nozzle is 400 μm And be connected with constant flow pump 3 through independent liquid delivery pipeline, the collection container 8 that has agitator 9 is placed under the coaxial nozzle 4, ultrasonic transducer 7 is connected on the coaxial nozzle 4, ultrasonic transducer 7 The...

Embodiment 2

[0034] Embodiment 2, the preparation device of pulse release microsphere such as figure 1 As shown, it includes: constant flow pump 1 , constant flow pump 2 , constant flow pump 3 , coaxial nozzle 4 , frequency generator 5 , signal amplifier 6 , ultrasonic transducer 7 , collection container 8 and agitator 9 . The coaxial nozzle 4 is a concentric three-port nozzle, wherein the inner diameter of the inner nozzle is 100 μm It is also connected to the constant flow pump 1 through an independent liquid delivery pipeline, and the inner diameter of the middle nozzle is 200 μm It is connected with the constant flow pump 2 through an independent liquid delivery pipeline, and the inner diameter of the outer nozzle is 400 μm And be connected with constant flow pump 3 through independent liquid delivery pipeline, the collection container 8 that has agitator 9 is placed under the coaxial nozzle 4, ultrasonic transducer 7 is connected on the coaxial nozzle 4, ultrasonic transducer 7 The...

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Abstract

The invention discloses a device and a method for preparing pulsatile release microspheres. The device comprises three constant-flow pumps, coaxial nozzles, a frequency generator, a signal amplifier, an ultrasonic transducer, a collection container and a stirrer. The coaxial nozzles are three homocentric nozzles comprising an inner nozzle, a middle nozzle and an outer nozzle. The inner nozzle, the middle nozzle and the outer nozzle are connected respectively to the three constant-flow pumps by independent liquid delivery pipes and respectively convey a drug solution, a polymer solution and a stabilizing solution. The method comprises that through adjustment of flowing rates of the constant-flow pumps, jet flows produced by the coaxial nozzles; the ultrasonic transducer vibrates and resonates with the coaxial nozzles so that the jet flows are broken into uniform micro-droplets; the micro-droplets drop in the collection container with the stirrer; and particles prepared by the previous step are polymer solution-coated drugs and contact with the stabilizing solution so that a polymer is precipitated and is solidified into core-shell microspheres. Microsphere drug release is controlled by properties of a polymer and after a polymer shell is degraded, a drug is released intensively in a pulse way.

Description

technical field [0001] The invention relates to a preparation technology of pulsed microspheres, in particular to a device and a method for preparing microspheres by an acoustic wave excitation atomization technique. Background technique [0002] In recent years, the long-acting and sustained-release dosage forms of protein and polypeptide drugs have become a research hotspot. After injecting this type of drug into the human body, if the drug can be released regularly and quantitatively according to the needs of physiology and treatment, it will be more beneficial to the curative effect of the drug. Drugs released in vivo such as hormones showing a clear circadian rhythm have extensive first-pass effects, interact with receptors for long-term stimulation to inactivate them, and produce drug-resistant drugs, as well as vaccines that require multiple vaccinations and pulse-type drug delivery. More ideally, pulse-type vaccines can replace the current common multiple vaccinatio...

Claims

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Application Information

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IPC IPC(8): B01J13/04
Inventor 胡英钦富华
Owner ZHEJIANG PHARMA COLLEGE
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